Tg(Nphs1-cre)33Mska
Transgene Detail

Summary

• Symbol: Tg(Nphs1-cre)33Mska
• Name: transgene insertion 33, Taiji Matsusaka
• MGI ID: MGI:3762483
• Synonyms: Nphs1-Cre
• Transgene: Tg(Nphs1-cre)33Mska Location: unknown
• Alliance: Tg(Nphs1-cre)33Mska page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1 x C57BL/6N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nphs1-cre)33Mska expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nphs1 (MGI:1859637)

• Mutation details: The cre recombinase cDNA was combined with a 5.5kb mouse Nphs1 promoter fragment and intron of the rabbit beta-globin gene. The construct was injected into fertilized eggs from (C57BL/6 x DBA/2) x C57BL/6N mice. Cre mRNA was detected in the kidney by Northern blot in five lines, and Cre protein was detected in podocytes by immunohistochemistry in four lines. Line 33 was established by backcrossing to C57BL/6N mice. (J:126591)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nphs1 (mouse) Summary of all recombinase alleles driven by Nphs1. Comparative matrix view of recombinase activities Alliance mouse Nphs1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:126591 Asano T, et al., Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. J Am Soc Nephrol. 2005 Aug;16(8):2257-62
• All: 11 reference(s)