Tg(MMTV-neu/OT-I/OT-II)CBnel
Transgene Detail
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Symbol: |
Tg(MMTV-neu/OT-I/OT-II)CBnel |
Name: |
transgene insertion C, Brad Nelson |
MGI ID: |
MGI:3761163 |
Synonyms: |
MMTV-HER2/Neu-Ovalbumin, neuOT-I/OT-II |
Transgene: |
Tg(MMTV-neu/OT-I/OT-II)CBnel Location: unknown
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Alliance: |
Tg(MMTV-neu/OT-I/OT-II)CBnel page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(MMTV-neu/OT-I/OT-II)CBnel expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Erbb2 (24337) |
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Mutation details: The transgene construct was designed to tag T cell receptor-recognized ovalbumin epitopes SIIFEKL (CD8+, OT-1) and ISQAVHAAHAEINEAGR (CD4+, OT-II)with the rat Erbb2/HER-2/neu oncogene under the control of an MMTV promoter creating a fusion protein (termed neuOT-I/OT-II). The vector was injected into C57BL/6 oocytes. Line C was selected for further studies based on mammary-specific expression and favorable tumor latency and frequency.
(J:122846)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:122846 Wall EM, et al., Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res. 2007 Jul 1;67(13):6442-50 |
All: |
4 reference(s) |
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