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Tg(Camk2a-rtTA)1237Kndl
Transgene Detail
Summary
Symbol: Tg(Camk2a-rtTA)1237Kndl
Name: transgene insertion 1237, Eric R Kandel
MGI ID: MGI:3716991
Synonyms: CamKIIalpha promoter-rtTA transgene, CamKII-rtTA2, line 1237
Transgene: Tg(Camk2a-rtTA)1237Kndl  Location: unknown  
Alliance: Tg(Camk2a-rtTA)1237Kndl page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThe transgene comprises 8.5 kb of upstream flanking DNA and 85 bp of the 5', noncoding exon of the mouse calcium/calmodulin-dependent protein kinase II alpha gene, an artificial intron and splice signal, the coding sequence for the reverse tetracycline-regulated transactivator (rtTA) protein and an SV40 polyadenylation signal. Maximal doxycycline induction of mice bearing both this transgene and a lacZ reporter transgene under control of the tetracycline operator (tetO) demonstrated expression in the CA1 and CA2 regions, but only minimal expression in the CA3 region, of the hippocampus; in the dentate gyrus; in both superficial layers and a deep layer of the cortex; and in the septum and striatum. (J:123059)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two transgenic lines, designated 1237 and 1076, were developed. Data were reported only for the former; authors state that results for line 1076 are similar to those for line 1237.
References
Original:  J:123059 Mansuy IM, et al., Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron. 1998 Aug;21(2):257-65
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory