Tg(KRT5-Ccnd2)2102Mlrp
Transgene Detail

Summary

• Symbol: Tg(KRT5-Ccnd2)2102Mlrp
• Name: transgene insertion 2102, Marcelo L Rodriguez-Puebla
• MGI ID: MGI:2389095
• Transgene: Tg(KRT5-Ccnd2)2102Mlrp Location: unknown
• Alliance: Tg(KRT5-Ccnd2)2102Mlrp page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Ccnd2)2102Mlrp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccnd2 (MGI:88314)

• Tg(KRT5-Ccnd2)2102Mlrp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: Murine Ccnd2 cDNA sequence preceded by a beta-globin intron was ligated to 5.2 kb of bovine KRT5 regulatory sequence. The KRT5 promoter directed expression in basal cells of squamous stratified epithelia. Expression of the transgenic protein was detected by Western blot analysis of epidermal tissue. Quantification of the Western blot results indicated a nearly two-fold increase relative to wild-type samples. (J:64388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:64388 Rodriguez-Puebla ML, et al., Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia. Am J Pathol. 2000 Sep;157(3):1039-50
• All: 3 reference(s)