Tg(HLA-A/H2-D/B2M)1Bpe
Transgene Detail

Summary

• Symbol: Tg(HLA-A/H2-D/B2M)1Bpe
• Name: transgene insertion 1, Beatrice Perarnau
• MGI ID: MGI:3711164
• Synonyms: HHD, HHD II
• Transgene: Tg(HLA-A/H2-D/B2M)1Bpe Location: unknown
• Alliance: Tg(HLA-A/H2-D/B2M)1Bpe page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-A/H2-D/B2M)1Bpe expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

  mouse

  H2-D (MGI:1933561)
• Mutation details: This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-D^b. (J:41077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available

Notes

The HHD construct was also used to create transgenic mice on the NOD background in J:121685.

References

• Original: J:41077 Pascolo S, et al., HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med. 1997 Jun 16;185(12):2043-51
• All: 37 reference(s)