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Fam129c Gene Detail
Summary
  • Symbol
    Fam129c
  • Name
    family with sequence similarity 129, member C
  • Synonyms
    Bcnp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3686743
    NCBI Gene: 100037278
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71597648-71607936 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3686743
protein coding gene Chr8:71596356-71608149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033757
protein coding gene Chr8:72008992-72021009 (+)
A/J MGP_AJ_G0033740
protein coding gene Chr8:69072282-69082566 (+)
AKR/J MGP_AKRJ_G0033666
protein coding gene Chr8:71106437-71117730 (+)
BALB/cJ MGP_BALBcJ_G0033736
protein coding gene Chr8:69243953-69255807 (+)
C3H/HeJ MGP_C3HHeJ_G0033446
protein coding gene Chr8:71694019-71703649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034254
protein coding gene Chr8:74748686-74760804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031196
protein coding gene Chr8:63706817-63718288 (+)
CAST/EiJ MGP_CASTEiJ_G0032771
protein coding gene Chr8:71152248-71162752 (+)
CBA/J MGP_CBAJ_G0033424
protein coding gene Chr8:77399139-77408622 (+)
DBA/2J MGP_DBA2J_G0033578
protein coding gene Chr8:68801058-68810869 (+)
FVB/NJ MGP_FVBNJ_G0033520
protein coding gene Chr8:67888586-67898586 (+)
LP/J MGP_LPJ_G0033665
protein coding gene Chr8:71982096-71993339 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033567
protein coding gene Chr8:79941192-79952768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034271
protein coding gene Chr8:71177868-71188909 (+)
PWK/PhJ MGP_PWKPhJ_G0032478
protein coding gene Chr8:68085199-68095813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032315
protein coding gene Chr8:70122371-70132220 (+)
WSB/EiJ MGP_WSBEiJ_G0032887
protein coding gene Chr8:71521578-71533878 (+)



Homology
more
  • Human Ortholog
    NIBAN3, niban apoptosis regulator 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NIBAN3, niban apoptosis regulator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCNP1, FAM129C
  • Links
    NCBI Gene ID: 199786
    neXtProt AC: NX_Q86XR2
    UniProt: Q86XR2

  • Chr Location
    19p13.11; chr19:17523301-17556755 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show impaired B-cell maturation, a reduction of B-1a cells, enhanced survival and proliferation of spleen B cells in response to stimulation, enhanced humoral immune responses, elevated levels of serum IgM and IgG3 antibodies and B-cell expansion in lymphoid organs.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043243 Ensembl Gene Model | MGI Sequence Detail 10289 C57BL/6J ±  kb
transcript ENSMUST00000143662 Ensembl | MGI Sequence Detail 2267 Not Applicable  
polypeptide ENSMUSP00000123432 Ensembl | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Phenotypes 7
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
  • Latest
    J:282961 Hong R, et al., Distinct roles of BCNP1 in B-cell development and activation. Int Immunol. 2020 Jan 9;32(1):17-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory