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Spocd1 Gene Detail
Summary
  • Symbol
    Spocd1
  • Name
    SPOC domain containing 1
  • Synonyms
    OTTMUSG00000009522
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652045
    NCBI Gene: 622480
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:129929249-129957115 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.43 cM
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652045
protein coding gene Chr4:129928767-129957115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028840
protein coding gene Chr4:131908160-131935851 (+)
A/J MGP_AJ_G0028799
protein coding gene Chr4:126616290-126645115 (+)
AKR/J MGP_AKRJ_G0028752
protein coding gene Chr4:130157327-130189591 (+)
BALB/cJ MGP_BALBcJ_G0028822
protein coding gene Chr4:127224962-127254585 (+)
C3H/HeJ MGP_C3HHeJ_G0028536
protein coding gene Chr4:130239701-130249098 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029264
protein coding gene Chr4:136853057-136880613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026536
protein coding gene Chr4:119740764-119769814 (+)
CAST/EiJ MGP_CASTEiJ_G0027968
protein coding gene Chr4:128404867-128436691 (+)
CBA/J MGP_CBAJ_G0028502
protein coding gene Chr4:140322489-140353090 (+)
DBA/2J MGP_DBA2J_G0028651
protein coding gene Chr4:127051567-127079956 (+)
FVB/NJ MGP_FVBNJ_G0028618
protein coding gene Chr4:125830026-125862941 (+)
LP/J MGP_LPJ_G0028752
protein coding gene Chr4:132200511-132256444 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028644
protein coding gene Chr4:145044228-145071765 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029302
protein coding gene Chr4:130524273-130557286 (+)
PWK/PhJ MGP_PWKPhJ_G0027690
protein coding gene Chr4:123662633-123690733 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027516
protein coding gene Chr4:126406183-126434321 (+)
WSB/EiJ MGP_WSBEiJ_G0028049
protein coding gene Chr4:130666822-130697399 (+)



Homology
more
  • Human Ortholog
    SPOCD1, SPOC domain containing 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SPOCD1, SPOC domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R146
  • Links
    NCBI Gene ID: 90853
    neXtProt AC: NX_Q6ZMY3
    UniProt: Q6ZMY3

  • Chr Location
    1p35.2; chr1:31790422-31816051 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects DNA methylation of transposable elements, leading to male sterility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028784 Ensembl Gene Model | MGI Sequence Detail 27867 C57BL/6J ±  kb
    transcript ENSMUST00000084263 Ensembl | MGI Sequence Detail 3096 Not Applicable  
    polypeptide ENSMUSP00000081284 Ensembl | MGI Sequence Detail 936 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR012921 Spen paralogue and orthologue SPOC, C-terminal
      IPR003618 Transcription elongation factor S-II, central domain
      IPR036575 Transcription elongation factor S-II, central domain superfamily
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 17
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:295943 Zoch A, et al., SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. Nature. 2020 Aug;584(7822):635-639

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/12/2021
    MGI 6.16
    The Jackson Laboratory