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Prlh
Gene Detail
Symbol

Name
ID
Prlh
prolactin releasing hormone
MGI:3644668
Synonyms
EG623503
Feature Type
protein coding gene
Genetic Map
Chromosome 1
45.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:90953108-90954027 bp, + strand
From VEGA annotation of GRCm38

  920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

HCOP human homology predictions: PRLH
Gene Tree: Prlh

Human
homologs
PRLH, prolactin releasing hormone
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51052
neXtProt AC: NX_P81277

Human Synonyms: PRH, PRRP

Human Chr (Location): 2q37.3; chr2:237566574-237567175 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous mutation of this gene results in polyphagia; late-onset obesity and adiposity; increase in circulating insulin, leptin, and triglyceride levels; impaired glucose tolerance and insulin resistance; and attenuated responses to the anorexigenic signals cholecystokinin and leptin.
 
Human Diseases Modeled in Mice Using Prlh (1)    Mutations Annotated to Human Diseases (1)   
Gene Ontology
(GO)
classifications
Expression
Other mouse links: GEO   Expression Atlas
Molecular
reagents

Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000048409 (Evidence)
Ensembl Gene Model ENSMUSG00000090550 (Evidence)
Entrez Gene 623503 (Evidence)
UniGene 471593
Consensus CDS Project CCDS48318.1
International Mouse Phenotyping Consortium Status Prlh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048409 VEGA Gene Model | MGI Sequence Detail 920 C57BL/6J ±  kb
transcript OTTMUST00000124106 VEGA | MGI Sequence Detail 276 Not Applicable 
polypeptide OTTMUSP00000067586 VEGA | MGI Sequence Detail 86 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026194 Prolactin-releasing peptide
Protein Ontology PR:000013247 prolactin-releasing peptide
References
(Earliest) J:144728 De Santo C, et al., Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008 Dec;118(12):4036-48
(Latest) J:215557 Dodd GT, et al., The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49
All references(16)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory