About   Help   FAQ
Prlh Gene Detail
Summary
  • Symbol
    Prlh
  • Name
    prolactin releasing hormone
  • Synonyms
    EG623503
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644668
    NCBI Gene: 623503
  • Gene Overview
    MyGene.info: PRLH
Location & Maps
more
  • Genetic Map
    Chromosome 1, 45.81 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRLH, prolactin releasing hormone
  • Vertebrate Orthologs
    4
  • Human Ortholog
    PRLH, prolactin releasing hormone
    Orthology source: HomoloGene
  • Synonyms
    PRH, PRRP
  • Links
    NCBI Gene ID: 51052
    neXtProt AC: NX_P81277

  • Chr Location
    2q37.3; chr2:237566574-237567175 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Prlh mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Prlh
Homozygous mutation of this gene results in polyphagia; late-onset obesity and adiposity; increase in circulating insulin, leptin, and triglyceride levels; impaired glucose tolerance and insulin resistance; and attenuated responses to the anorexigenic signals cholecystokinin and leptin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048409 VEGA Gene Model | MGI Sequence Detail 920 C57BL/6J ±  kb
transcript OTTMUST00000124106 VEGA | MGI Sequence Detail 276 Not Applicable  
polypeptide OTTMUSP00000067586 VEGA | MGI Sequence Detail 86 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR026194 Prolactin-releasing peptide
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 15
    Diseases 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:144728 De Santo C, et al., Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008 Dec;118(12):4036-48
  • Latest
    J:215557 Dodd GT, et al., The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory