Prlh
Gene Detail

Symbol Name ID

Prlh prolactin releasing hormone MGI:3644668

Synonyms

EG623503

Feature Type

protein coding gene

Genetic Map

Chromosome 1

45.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:90953108-90954012 bp, + strand From NCBI annotation of GRCm38   905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Prlh

Human homologs

Human Homolog		PRLH, prolactin releasing hormone
NCBI Gene ID		51052
neXtProt AC		NX_P81277
Human Synonyms		PRH, PRRP
Human Chr (Location)		2q37.3; chr2:238475217-238475818 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in polyphagia, late-onset obesity and adiposity, increase in circulating insulin, leptin, and triglyceride levels, impaired glucose tolerance and insulin resistance and attenuated responses to the anorexigenic signals cholecystokinin and leptin.

 
Human Diseases Modeled Using Mouse Prlh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	autonomic nervous system development, eating behavior, ...
Component	cytoplasm
Function	neuropeptide hormone activity, prolactin-releasing peptide receptor binding

Expression

External Resources: GEO   ArrayExpress

Molecular reagents

Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000090550 (Evidence)
Entrez Gene	623503 (Evidence)
UniGene	471593
NIA Mouse Gene Index	U000597
Consensus CDS Project	CCDS48318.1
International Mouse Knockout Project Status	Prlh

Sequences

Length	Strain/Species
genomic	623503	NCBI Gene Model | MGI Sequence Detail	905	C57BL/6J
transcript	NM_001101647	RefSeq | MGI Sequence Detail	261	Not Specified
polypeptide	NP_001095117	RefSeq | MGI Sequence Detail	86	Not Specified

All sequences(10) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026194	Prolactin-releasing peptide
Protein Ontology	PR:000013247	prolactin-releasing peptide

References

(Earliest) J:144728 De Santo C, et al., Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008 Dec;118(12):4036-48
(Latest) J:179077 Sasaki K, et al., Acetylation of Prrp K150 regulates the subcellular localization. Gene. 2012 Jan 1;491(1):13-9
All references(15)