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Prlh
Gene Detail
 Symbol
Name
ID
Prlh
prolactin releasing hormone
MGI:3644668
Synonyms EG623503
Feature Type protein coding gene
Genetic Map
Chromosome 1
45.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:90953108-90954012 bp, + strand
From NCBI annotation of GRCm38

  905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

Gene Tree: Prlh

Human
homologs
Human Homolog PRLH, prolactin releasing hormone
NCBI Gene ID 51052
neXtProt AC  NX_P81277
Human Synonyms  PRH, PRRP
Human Chr (Location)  2q37.3; chr2:237566574-237567175 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Homozygous mutation of this gene results in polyphagia, late-onset obesity and adiposity, increase in circulating insulin, leptin, and triglyceride levels, impaired glucose tolerance and insulin resistance and attenuated responses to the anorexigenic signals cholecystokinin and leptin.
 
Human Diseases Modeled Using Mouse Prlh (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process autonomic nervous system development, eating behavior, ...
Component cytoplasm
Function neuropeptide hormone activity, prolactin-releasing peptide receptor binding
Expression
External Resources: GEO   ArrayExpress
Molecular
reagents

Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000090550 (Evidence)
Entrez Gene623503 (Evidence)
UniGene471593
NIA Mouse Gene IndexU000597
Consensus CDS ProjectCCDS48318.1
International Mouse Knockout Project StatusPrlh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 623503 NCBI Gene Model | MGI Sequence Detail 905 C57BL/6J ±  kb
transcript NM_001101647 RefSeq | MGI Sequence Detail 261 Not Specified 
polypeptide NP_001095117 RefSeq | MGI Sequence Detail 86 Not Specified 

For the selected sequences
All sequences(12) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026194 Prolactin-releasing peptide
Protein Ontology PR:000013247 prolactin-releasing peptide
References (Earliest) J:144728 De Santo C, et al., Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008 Dec;118(12):4036-48
(Latest) J:179077 Sasaki K, et al., Acetylation of Prrp K150 regulates the subcellular localization. Gene. 2012 Jan 1;491(1):13-9
All references(15)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory