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Dnaaf5 Gene Detail
Summary
  • Symbol
    Dnaaf5
  • Name
    dynein, axonemal assembly factor 5
  • Synonyms
    Heatr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3616079
    NCBI Gene: 433956
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139150223-139186505 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 78.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3616079
protein coding gene Chr5:139150223-139186510 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030276
protein coding gene Chr5:144098534-144137513 (+)
A/J MGP_AJ_G0030245
protein coding gene Chr5:138000886-138037891 (+)
AKR/J MGP_AKRJ_G0030177
protein coding gene Chr5:142304585-142341591 (+)
BALB/cJ MGP_BALBcJ_G0030262
protein coding gene Chr5:139246728-139283452 (+)
C3H/HeJ MGP_C3HHeJ_G0029973
protein coding gene Chr5:143074009-143109908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030707
protein coding gene Chr5:149415973-149454551 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027925
protein coding gene Chr5:131863609-131901827 (+)
CAST/EiJ MGP_CASTEiJ_G0029378
protein coding gene Chr5:142486760-142523088 (+)
CBA/J MGP_CBAJ_G0029943
protein coding gene Chr5:155575971-155616896 (+)
DBA/2J MGP_DBA2J_G0030093
protein coding gene Chr5:137819128-137854750 (+)
FVB/NJ MGP_FVBNJ_G0030048
protein coding gene Chr5:136915330-136952472 (+)
LP/J MGP_LPJ_G0030179
protein coding gene Chr5:144722677-144758908 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030079
protein coding gene Chr5:158268900-158307207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030747
protein coding gene Chr5:142112655-142149819 (+)
PWK/PhJ MGP_PWKPhJ_G0029093
protein coding gene Chr5:136809224-136848071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028929
protein coding gene Chr5:139796102-139836766 (+)
WSB/EiJ MGP_WSBEiJ_G0029452
protein coding gene Chr5:142873435-142914909 (+)



Homology
more
  • Human Ortholog
    DNAAF5, dynein axonemal assembly factor 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNAAF5, dynein axonemal assembly factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD18, HEATR2
  • Links
    NCBI Gene ID: 54919
    neXtProt AC: NX_Q86Y56
    UniProt: Q86Y56

  • Chr Location
    7p22.3; chr7:726701-786479 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DNAAF5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 433956 NCBI Gene Model | MGI Sequence Detail 36283 C57BL/6J ±  kb
transcript NM_001081265 RefSeq | MGI Sequence Detail 3438 C57BL/6  
polypeptide B9EJR8 UniProt | EBI | MGI Sequence Detail 853 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141278
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:215975 Diggle CP, et al., HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. PLoS Genet. 2014 Sep;10(9):e1004577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory