Tg(Camk2a-MAPT*R406W)748Atak
Transgene Detail

Summary

• Symbol: Tg(Camk2a-MAPT*R406W)748Atak
• Name: transgene insertion 748, Akihiko Takashima
• MGI ID: MGI:3603948
• Transgene: Tg(Camk2a-MAPT*R406W)748Atak Location: unknown
• Alliance: Tg(Camk2a-MAPT*R406W)748Atak page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-MAPT*R406W)748Atak expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: An 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II alpha promoter was used to drive the human microtubule-associated protein tau with the R406W mutation postnataly in forebrain neurons. Protein was expressed the greatest in the hippocampus, followed in decreasing amounts by the neocortex, the olfactory bulb, the striatum, and the thalamus. Mutant protein was barely detectable in the midbrain, the cerebellum and the spinal cord. Lines 502, 492 and 483 demonstrated similar expression patterns. (J:100958)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100958 Tatebayashi Y, et al., Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901
• All: 3 reference(s)