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Pramel17 Gene Detail
Summary
  • Symbol
    Pramel17
  • Name
    PRAME like 17
  • Synonyms
    B020004J07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588238
    NCBI Gene: 545662
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:101692166-101701219 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588238
protein coding gene Chr4:101692166-101701220 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028496
protein coding gene Chr4:102162685-102166109 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0028190
protein coding gene Chr4:101768429-101777649 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028916
protein coding gene Chr4:106003315-106014486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026208
protein coding gene Chr4:93850193-93853497 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028159
protein coding gene Chr4:109355982-109375096 (-)
DBA/2J MGP_DBA2J_G0028309
protein coding gene Chr4:98275710-98285723 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0028409
protein coding gene Chr4:102458473-102465247 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0027355
protein coding gene Chr4:96449321-96452615 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027177
protein coding gene Chr4:98663189-98665733 (-)
WSB/EiJ MGP_WSBEiJ_G0027708
protein coding gene Chr4:101395375-101398128 (-)



Homology
more
  • Human Ortholog
    PRAMEF1, PRAME family member 1
  • Vertebrate Orthologs
    22
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAMEF1, PRAME family member 1
  • Links
    NCBI Gene ID: 65121
    neXtProt AC: NX_O95521
    UniProt: O95521

  • Chr Location
    1p36.21; chr1:12791397-12796628 (+)  GRCh38.p7




  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Links
    NCBI Gene ID: 400736
    neXtProt AC: NX_Q5VWM6

  • Chr Location
    1p36.21; chr1:13196188-13201409 (-)  GRCh38.p7

  • Human Ortholog
    PRAMEF15, PRAME family member 15
  • Links
    NCBI Gene ID: 653619
    UniProt: P0DUQ1

  • Chr Location
    1p36.21; chr1:13315581-13322595 (+)  GRCh38.p7


  • Human Ortholog
    PRAMEF18, PRAME family member 18
  • Links
    NCBI Gene ID: 391003
    neXtProt AC: NX_Q5VWM3

  • Chr Location
    1p36.21; chr1:13222695-13226154 (-)  GRCh38.p7


  • Human Ortholog
    PRAMEF2, PRAME family member 2
  • Synonyms
    DJ845O24.3
  • Links
    NCBI Gene ID: 65122
    neXtProt AC: NX_O60811
    UniProt: O60811

  • Chr Location
    1p36.21; chr1:12857086-12861909 (+)  GRCh38.p7

  • Human Ortholog
    PRAMEF20, PRAME family member 20
  • Synonyms
    PRAMEF21
  • Links
    NCBI Gene ID: 645425
    neXtProt AC: NX_Q5VT98
    UniProt: Q5VT98

  • Chr Location
    1p36.21; chr1:13410450-13421328 (+)  GRCh38.p7


  • Human Ortholog
    PRAMEF26, PRAME family member 26
  • Synonyms
    PRAMEF25
  • Links
    NCBI Gene ID: 645359
    neXtProt AC: NX_A6NGN4
    UniProt: H0Y7S4

  • Chr Location
    1p36.21; chr1:13148905-13153111 (-)  GRCh38.p7




  • Human Ortholog
    PRAMEF5, PRAME family member 5
  • Synonyms
    PRAMEF23, PRAMEF5L
  • Links
    NCBI Gene ID: 343068
    neXtProt AC: NX_Q5TYX0
    UniProt: Q5TYX0

  • Chr Location
    1p36.21; chr1:13254198-13263435 (+)  GRCh38.p7



  • Human Ortholog
    PRAMEF8, PRAME family member 8
  • Synonyms
    PRAMEF24
  • Links
    NCBI Gene ID: 391002
    neXtProt AC: NX_Q5VWM4
    UniProt: Q5VWM4

  • Chr Location
    1p36.21; chr1:13281223-13285137 (-)  GRCh38.p7

  • Human Ortholog
    PRAMEF9, PRAME family member 9
  • Links
    NCBI Gene ID: 343070
    UniProt: P0DUQ2

  • Chr Location
    1p36.21; chr1:13175281-13179132 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRAME associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 545662 NCBI Gene Model | MGI Sequence Detail 9054 C57BL/6J ±  kb
    transcript NM_001033790 RefSeq | MGI Sequence Detail 1975 C57BL/6  
    polypeptide NP_001028962 RefSeq | MGI Sequence Detail 476 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR032675 Leucine-rich repeat domain superfamily
      IPR026271 PRAME family
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:284179 De Iaco A, et al., DUX is a non-essential synchronizer of zygotic genome activation. Development. 2020 Jan 23;147(2):dev177725

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/26/2022
    MGI 6.22
    The Jackson Laboratory