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Epha10 Gene Detail
Summary
  • Symbol
    Epha10
  • Name
    Eph receptor A10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3586824
    NCBI Gene: 230735
  • Gene Overview
    MyGene.info: EPHA10
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124881785-124917800 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3586824
protein coding gene Chr4:124880899-124917800 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028758
protein coding gene Chr4:126444519-126485944 (+)
A/J MGP_AJ_G0028717
protein coding gene Chr4:121481949-121518724 (+)
AKR/J MGP_AKRJ_G0028670
protein coding gene Chr4:124799355-124843678 (+)
BALB/cJ MGP_BALBcJ_G0028740
protein coding gene Chr4:122058595-122094203 (+)
C3H/HeJ MGP_C3HHeJ_G0028454
protein coding gene Chr4:124892117-124928003 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029182
protein coding gene Chr4:131303226-131349625 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026455
protein coding gene Chr4:114652879-114688387 (+)
CAST/EiJ MGP_CASTEiJ_G0027887
protein coding gene Chr4:122956523-122999729 (+)
CBA/J MGP_CBAJ_G0028420
protein coding gene Chr4:134574844-134620489 (+)
DBA/2J MGP_DBA2J_G0028569
protein coding gene Chr4:121954506-121991556 (+)
FVB/NJ MGP_FVBNJ_G0028536
protein coding gene Chr4:120580522-120619312 (+)
LP/J MGP_LPJ_G0028670
protein coding gene Chr4:126734250-126776530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028562
protein coding gene Chr4:139561964-139604224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029220
protein coding gene Chr4:125164941-125206652 (+)
PWK/PhJ MGP_PWKPhJ_G0027608
protein coding gene Chr4:118357097-118417535 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027434
protein coding gene Chr4:120936119-120979918 (+)
WSB/EiJ MGP_WSBEiJ_G0027967
protein coding gene Chr4:125239766-125282492 (+)



Homology
more
  • Human Ortholog
    EPHA10, EPH receptor A10
  • Vertebrate Orthologs
    5
  • Human Ortholog
    EPHA10, EPH receptor A10
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 284656
    neXtProt AC: NX_Q5JZY3
    UniProt: Q5JZY3

  • Chr Location
    1p34.3; chr1:37713888-37765152 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Epha10
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 230735 NCBI Gene Model | MGI Sequence Detail 36016 C57BL/6J ±  kb
transcript NM_001256432 RefSeq | MGI Sequence Detail 5187 C57BL/6  
polypeptide Q8BYG9 UniProt | EBI | MGI Sequence Detail 1007 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR008979 Galactose-binding-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:245526 Bibollet-Bahena O, et al., A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory