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Agap2 Gene Detail
Summary
  • Symbol
    Agap2
  • Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  • Synonyms
    Centg1, PIKE-A, PIKE-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:3580016
    NCBI Gene: 216439
  • Gene Overview
    MyGene.info: AGAP2
Location & Maps
more
  • Sequence Map
    Chr10:127078907-127093169 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14263 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CENTG1, GGAP2, PIKE
  • Links
    NCBI Gene ID: 116986
    neXtProt AC: NX_Q99490

  • Chr Location
    12q14.1; chr12:57723761-57742201 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired lactation due to abnormal mammary gland growth during lactation, failure of insulin-suppressed gluconeogenesis, and hyperglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025422 Ensembl Gene Model | MGI Sequence Detail 14263 C57BL/6J ±  kb
transcript ENSMUST00000039259 Ensembl | MGI Sequence Detail 5633 Not Applicable  
polypeptide ENSMUSP00000043466 Ensembl | MGI Sequence Detail 1186 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003816 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR001164 Arf GTPase activating protein
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:228362 Gross C, et al., Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Rep. 2015 May 5;11(5):727-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory