Tg(Hc)388Ukb
Transgene Detail

Summary

• Symbol: Tg(Hc)388Ukb
• Name: transgene 388, Universitatsklinikum Bonn
• MGI ID: MGI:3527963
• Transgene: Tg(Hc)388Ukb Location: unknown
• Alliance: Tg(Hc)388Ukb page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hc)388Ukb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hc (MGI:96031)

• Mutation details: The transgene, comprising the functional allele of the gene encoding hemolytic complement (also called complement factor 5 or C5) and its flanking DNA from C57BL/6J, was derived by deletion of nucleotides 117,600 - 191,329 of the bacterial artificial chromosome (BAC) RP23-223C17 via ET recombination. (J:100159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This was one of four transgenic lines created in the hemolytic complement-deficient strain FVB/NJ: Tg(Hc)244Ukb, Tg(Hc)368Ukb, Tg(Hc)388Ukb and Tg(Hc)392Ukb. No distinction was made among them by the authors.

Transgenic mice had serum hemolytic complement (C5) activity 75-84% that of hemolytic complement-positive BALB/cJ mice; no activity was present in serum of nontransgenic littermates. Following 6 weeks' challenge with carbon tetrachloride, transgenic mice exhibited more advanced hepatic fibrosis (stage 2.0 +/- 0.10 vs. 1.46 +/- 0.14) and greater liver collagen concentration (352 +/- 12 vs. 227 +/- 10 ug/g liver) than did control littermates.

References

• Original: J:100159 Hillebrandt S, et al., Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet. 2005 Aug;37(8):835-43
• All: 1 reference(s)