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Mdc1
Gene Detail
 Symbol
Name
ID
Mdc1
mediator of DNA damage checkpoint 1
MGI:3525201
Synonyms NFBD1
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:35841515-35859670 bp, + strand
From VEGA annotation of GRCm38

  18156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:67092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mdc1

Human
homologs
Human Homolog MDC1, mediator of DNA-damage checkpoint 1
NCBI Gene ID 9656
neXtProt AC  NX_Q14676
Human Synonyms  NFBD1
Human Chr (Location)  6p21.3; chr6:30699807-30717681 (-)  GRCh38
Alleles
and
phenotypes
All alleles(38) : Gene trapped(35) Targeted(2) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are smaller and display increased susceptibility to ionizing radiation, male infertility, T and B cell abnormalities, and increased genomic instability.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component chromosome, focal adhesion, ...
Function FHA domain binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (35)    Tissues (4)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 35
cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(71) cDNA(71)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037407 (Evidence)
Ensembl Gene ModelENSMUSG00000061607 (Evidence)
Entrez Gene240087 (Evidence)
UniGene218511
DFCITC1597037, TC1601339, TC1601956
DoTSDT.530482, DT.94123626, DT.94123627
NIA Mouse Gene IndexU135300
PDB3VA1, 3VA4
Consensus CDS ProjectCCDS37604.1
International Mouse Knockout Project StatusMdc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037407 VEGA Gene Model | MGI Sequence Detail 18156 C57BL/6J ±  kb
transcript OTTMUST00000096524 VEGA | MGI Sequence Detail 7335 Not Applicable 
polypeptide OTTMUSP00000053942 VEGA | MGI Sequence Detail 1708 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(33) UniProt(3)
Polymorphisms SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000010258 mediator of DNA damage checkpoint protein 1
References (Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:201067 Li M, et al., The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes Dev. 2013 Aug 15;27(16):1752-68
All references(46)
Other
accession IDs
MGI:3035026

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory