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Tg(TetO-Erbb2)1Lach
Transgene Detail
Summary
Symbol: Tg(TetO-Erbb2)1Lach
Name: transgene insertion 1, Lewis A Chodosh
MGI ID: MGI:3511877
Synonyms: TAN, TetO-Her2, TetO-NeuNT
Transgene: Tg(TetO-Erbb2)1Lach  Location: unknown  
Alliance: Tg(TetO-Erbb2)1Lach page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(TetO-Erbb2)1Lach expresses 1 gene
 
Mutation detailsThe transgene consists of the tet operator driving expression of a bicistronic transcript encoding activated rat Erbb2 (Neu), having the Val664Leu missense mutation, and firefly luciferase, the latter translated from an internal ribosome binding sequence (IRES) upstream of its coding sequence. In a mouse bitransgenic for this transgene and a tetracycline transactivator transgene, administration of doxycycline reversibly induces expression of Erbb2 and luciferase in tissues where the transactivator is expressed. (J:81083)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(TetO-Erbb2)1Lach
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:81083 Moody SE, et al., Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell. 2002 Dec;2(6):451-61
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory