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Prr7 Gene Detail
Summary
  • Symbol
    Prr7
  • Name
    proline rich 7 (synaptic)
  • Feature Type
    protein coding gene
  • IDs
    MGI:3487246
    NCBI Gene: 432763
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55464267-55473154 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3487246
protein coding gene Chr13:55464267-55473162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020598
protein coding gene Chr13:54949444-54958332 (+)
A/J MGP_AJ_G0020552
protein coding gene Chr13:52918323-52927220 (+)
AKR/J MGP_AKRJ_G0020530
protein coding gene Chr13:54483726-54492614 (+)
BALB/cJ MGP_BALBcJ_G0020548
protein coding gene Chr13:53150470-53159367 (+)
C3H/HeJ MGP_C3HHeJ_G0020347
protein coding gene Chr13:54292053-54300950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020982
protein coding gene Chr13:56609004-56617892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018564
protein coding gene Chr13:50857463-50866067 (+)
CAST/EiJ MGP_CASTEiJ_G0019861
protein coding gene Chr13:54396037-54404929 (+)
CBA/J MGP_CBAJ_G0020307
protein coding gene Chr13:58782702-58791845 (+)
DBA/2J MGP_DBA2J_G0020430
protein coding gene Chr13:52470297-52479185 (+)
FVB/NJ MGP_FVBNJ_G0020409
protein coding gene Chr13:51938033-51947621 (+)
LP/J MGP_LPJ_G0020506
protein coding gene Chr13:55206918-55215809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020438
protein coding gene Chr13:58251390-58260278 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021025
protein coding gene Chr13:54062945-54071833 (+)
PWK/PhJ MGP_PWKPhJ_G0019617
protein coding gene Chr13:52494668-52503687 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019444
protein coding gene Chr13:52991907-53000553 (+)
WSB/EiJ MGP_WSBEiJ_G0019923
protein coding gene Chr13:54419980-54428871 (+)



Homology
more
  • Human Ortholog
    PRR7, proline rich 7, synaptic
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PRR7, proline rich 7, synaptic
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 80758
    neXtProt AC: NX_Q8TB68
    UniProt: Q8TB68

  • Chr Location
    5q35.3; chr5:177445936-177456701 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Prr7
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele are viable and fertile and exhibit no major defects in the immune system except for a slight decrease in the number of single positive CD4+ T cells in the thymus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034686 Ensembl Gene Model | MGI Sequence Detail 8888 C57BL/6J ±  kb
transcript ENSMUST00000046533 Ensembl | MGI Sequence Detail 1359 Not Applicable  
polypeptide ENSMUSP00000046776 Ensembl | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 1
Other
Accession IDs
less
MGI:3487238
References
more
  • Summaries
    All 29
    Diseases 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:265030 Lee SH, et al., Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018 Aug 24;9(1):3434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory