Prr7 MGI Mouse Gene Detail - MGI:3487246 - proline rich 7 (synaptic)

Symbol

Prr7
Name

proline rich 7 (synaptic)

Feature Type

protein coding gene
IDs

MGI:3487246
NCBI Gene: 432763
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:55612080-55620967 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

1 experiment

SNPs within 2kb

197 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3487246	protein coding gene	Chr13:55612080-55620968 (+)
129S1/SvImJ	ENSMUSG00200015690	protein coding gene	Chr13:52484650-52493537 (+)
A/J	ENSMUSG00195042848	protein coding gene	Chr13:51943438-51952334 (+)
AKR/J	ENSMUSG00220041201	protein coding gene	Chr13:51492034-51500921 (+)
BALB/cJ	ENSMUSG00180015811	protein coding gene	Chr13:52194701-52203597 (+)
C3H/HeJ	ENSMUSG00175033995	protein coding gene	Chr13:51981155-51990051 (+)
C57BL/6NJ	ENSMUSG00215029956	protein coding gene	Chr13:52014120-52023007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018564	protein coding gene	Chr13:50857463-50866067 (+)
CAST/EiJ	ENSTCUG00005038892	protein coding gene	Chr13:52406718-52415609 (+)
CBA/J	ENSMUSG00210038977	protein coding gene	Chr13:52185972-52194868 (+)
DBA/2J	ENSMUSG00185015792	protein coding gene	Chr13:53035988-53044875 (+)
FVB/NJ	ENSMUSG00205023775	protein coding gene	Chr13:51838750-51847637 (+)
JF1/MsJ	ENSUMUG00000023505	protein coding gene	Chr13:52427537-52436419 (+)
LP/J	ENSMUSG00230031256	protein coding gene	Chr13:62378076-62386966 (+)
NOD/ShiLtJ	ENSMUSG00190027490	protein coding gene	Chr13:52078918-52087806 (+)
NZO/HlLtJ	ENSMUSG00225033892	protein coding gene	Chr13:56107763-56116650 (+)
PWK/PhJ	ENSLUMG00010021379	protein coding gene	Chr13:51299528-51308405 (+)
SPRET/EiJ	ENSMSPG00010033487	protein coding gene	Chr13:51727379-51728747 (+)
WSB/EiJ	ENSIUOG00005021254	protein coding gene	Chr13:51509879-51518769 (+)

Human Ortholog

PRR7, proline rich 7, synaptic

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRR7, proline rich 7, synaptic
Links

HGNC:28130

NCBI Gene ID: 80758

UniProt: Q8TB68
Chr Location

5q35.3; chr5:177445995-177456291 (+) GRCh38

MGI Vertebrate Homology

Prr7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRR7
Gene Tree

Prr7

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Targeted

4
Genomic Mutations

2 involving Prr7
Find Mice (IMSR)

10 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile and exhibit no major defects in the immune system except for a slight decrease in the number of single positive CD4+ T cells in the thymus.

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All GO Annotations

50
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prr7

ZFIN prr7

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS26546.1

Ensembl

ENSMUSG00000034686 (Evidence)
NCBI Gene

432763

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034686	Ensembl Gene Model \| MGI Sequence Detail	8888	C57BL/6J	± kb
transcript	ENSMUST00000046533	Ensembl \| MGI Sequence Detail	1359	Not Applicable
polypeptide	ENSMUSP00000046776	Ensembl \| MGI Sequence Detail	269	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013309 proline-rich protein 7

(term hierarchy)
InterPro Domains

IPR051994 WW domain-binding

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All nucleic 8

cDNA 8

Microarray probesets 1

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MGI:3487238

Summaries

All 34

Diseases 1

Gene Ontology 7

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:265030 Lee SH, et al., Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018 Aug 24;9(1):3434

TSS for Prr7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119960	Chr13:55612050-55612132 (+)	11 bp
Tssr119961	Chr13:55619493-55619520 (+)	7,427 bp
Tssr119962	Chr13:55619529-55619570 (+)	7,470 bp
Tssr119963	Chr13:55619574-55619586 (+)	7,500 bp
Tssr119964	Chr13:55620100-55620115 (+)	8,028 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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