Tg(Myh6-Ppp3ca)37Eno
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ppp3ca)37Eno
• Name: transgene insertion 37, Eric N Olson
• MGI ID: MGI:3056186
• Synonyms: alpha-MHC-CnA*, CalTG, CN, CNA, MHC-CnA
• Transgene: Tg(Myh6-Ppp3ca)37Eno Location: unknown
• Alliance: Tg(Myh6-Ppp3ca)37Eno page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ppp3ca)37Eno expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppp3ca (MGI:107164)

• Mutation details: The promoter region of Myh6 drives expression of a constitutively active Ppp3ca cDNA in cardiomyocytes. This is a representative record representing Tg46, Tg22, Tg110, Tg106, Tg108, Tg41, Tg37, and Tg39 which vary in the number of copies of the transgene integrated but all have identical phenotypes. (J:93176)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93176 Molkentin JD, et al., A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998 May 17;93(2):215-28
• All: 47 reference(s)