Tg(BCL2)22Wehi
Transgene Detail

Summary

• Symbol: Tg(BCL2)22Wehi
• Name: transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:3052827
• Synonyms: 22Wehi, C-Emu-bcl-2-22, Emu2-22, Emu-bcl-2, Emu-bcl-2-22, EmuBcl-2.22, SV40-E-hbcl-2-22
• Transgene: Tg(BCL2)22Wehi Location: unknown
• Alliance: Tg(BCL2)22Wehi page

Transgene origin

• Strain of Origin: (C57BL/6JWehi x SJL/JWehi)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCL2)22Wehi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: The transgene construct consists of the human BCL2 cDNA in association with the Emu immunoglobulin heavy chain enhancer and SV40 promoter. (J:93111)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

In transgenic mice on a C57BL/6 background, expression of the transgene is restricted to the B cell lineage (no T-cell expression).

References

• Original: J:93111 Strasser A, et al., Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Curr Top Microbiol Immunol. 1990;166:175-81
• All: 89 reference(s)