Tg(Pax6-cre,GFP)2Pgr
Transgene Detail

Summary

• Symbol: Tg(Pax6-cre,GFP)2Pgr
• Name: transgene insertion 2, Peter Gruss
• MGI ID: MGI:3052661
• Synonyms: alpha-cre, alphaP0^CREiresGFP, aPax6-Cre, Pax6-aCre, Pax6-alpha-Cre, Tg(Pax6-cre,-GFP)2Pgr
• Transgene: Tg(Pax6-cre,GFP)2Pgr Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(Pax6-cre,GFP)2Pgr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pax6-cre,GFP)2Pgr involves 1 genes/genome features (Vmn2r71) View all
• Tg(Pax6-cre,GFP)2Pgr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax6 (MGI:97490)

• Mutation details: This transgene consists of a minimal promoter, 1.8 kb of murine Pax6 intron 4 encoding a retinal specific regulatory element, a cre recombinase gene, an IRES, a GFP gene, and a polyadenylation signal. Cre and GFP expression are seen in retinal progenitor cells. Line two contains 4 copies of the trandgene inserted into Chr 7 (Chr7: 8525949685287099) to produce a 27 kb deletion. (J:68851, J:325619)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax6 (mouse) Summary of all recombinase alleles driven by Pax6. Comparative matrix view of recombinase activities Alliance mouse Pax6 gene page

Disease models

Expression

In Mice Carrying this Mutation:

122 assay results 6 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pax6-cre,GFP)2Pgr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:68851 Marquardt T, et al., Pax6 is required for the multipotent state of retinal progenitor cells. Cell. 2001 Apr 6;105(1):43-55
• All: 148 reference(s)