Tg(Eno2tTA)5030Nes
Transgene Detail

Summary

• Symbol: Tg(Eno2tTA)5030Nes
• Name: transgene insertion 5030, Eric Nestler
• MGI ID: MGI:3051985
• Synonyms: A line, NSE-tTA, Tg(Eno2-tTA)ANes
• Transgene: Tg(Eno2tTA)5030Nes Location: unknown
• Alliance: Tg(Eno2tTA)5030Nes page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

B6.Cg-TgN(Eno2tTA)5030Nes mice selectively express tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).

References

• Original: J:92225 Chen J, et al., Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998 Sep;54(3):495-503
• All: 35 reference(s)