Tg(TcraH-Y,TcrbH-Y)71Vbo
Transgene Detail

Summary

• Symbol: Tg(TcraH-Y,TcrbH-Y)71Vbo
• Name: transgene insertion 71, Harald von Boehmer
• MGI ID: MGI:3044562
• Synonyms: B6.2.16, HY, H-Y, HY1.1, HY1.1 (Tcr-ab), H-Y TCR, HY TCR, HY-TCR, HyTcrTg, HY_TCRtg, H-Y Tg, T-cell receptor (alpha/beta) anti-Hy, TCR HY, Tg71
• Transgene: Tg(TcraH-Y,TcrbH-Y)71Vbo Location: unknown
• Alliance: Tg(TcraH-Y,TcrbH-Y)71Vbo page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraH-Y,TcrbH-Y)71Vbo expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The two transgenes comprise functionally rearranged T-cell receptor alpha and T-cell receptor beta genes, isolated from the cytotoxic T cell clone B6.2.16, that recognize the male-specific H-Y antigen in the context of the H2-D^b major histocompatibilty protein. The alpha chain transgene has the V-alpha3 gene segment joined to the J-alpha27 segment; the beta chain transgene joins V-beta8.2, D-beta1, J-beta2.3 and C-beta2. The two transgenes were co-injected into fertilized oocytes. The founder of line 71 carried four copies of the rearranged T-cell receptor alpha and two copies of the T-cell receptor beta transgenes. (J:51117, J:79738, J:90776)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TcraH-Y,TcrbH-Y)71Vbo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:79738 Kisielow P, et al., Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 1988 Jun 23;333(6175):742-6
• All: 223 reference(s)