Tg(INS-MT2A,Tyr)1Pne
Transgene Detail

Summary

• Symbol: Tg(INS-MT2A,Tyr)1Pne
• Name: transgene insertion 1, Paul N Epstein
• MGI ID: MGI:3044323
• Synonyms: HMT-1
• Transgene: Tg(INS-MT2A,Tyr)1Pne Location: unknown
• Alliance: Tg(INS-MT2A,Tyr)1Pne page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(INS-MT2A,Tyr)1Pne expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MT2A (4502)

  Mt2	(MGI:97172)

• Mutation details: This transgene expresses the full length human metallothionein II gene under the control of the human insulin promoter and first intron. A second transgene that expresses tyrosinase under the control of the tyrosinase promoter was coinjected with the first transgene, and appears to cosegregate. (J:90564)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90564 Chen H, et al., Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes. 2001 Sep;50(9):2040-6
• All: 5 reference(s)