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Nlrp2 Gene Detail
Summary
  • Symbol
    Nlrp2
  • Name
    NLR family, pyrin domain containing 2
  • Synonyms
    E330007A02Rik, Nalp2, Nbs1, Pan1, PYPAF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041206
    NCBI Gene: 232827
  • Gene Overview
    MyGene.info: NLRP2
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:5298547-5351035 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 3.07 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    309 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041206
protein coding gene Chr7:5298547-5351035 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031590
protein coding gene Chr7:2301523-2358075 (-)
A/J MGP_AJ_G0031562
protein coding gene Chr7:2253029-2305101 (-)
AKR/J MGP_AKRJ_G0031491
protein coding gene Chr7:2350250-2405938 (-)
BALB/cJ MGP_BALBcJ_G0031570
protein coding gene Chr7:2331609-2383246 (-)
C3H/HeJ MGP_C3HHeJ_G0031291
protein coding gene Chr7:2312364-2362333 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032032
protein coding gene Chr7:2329876-2395452 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030654
protein coding gene Chr7:2221656-2279774 (-)
CBA/J MGP_CBAJ_G0031249
protein coding gene Chr7:2568642-2623261 (-)
DBA/2J MGP_DBA2J_G0031408
protein coding gene Chr7:2258999-2327302 (-)
FVB/NJ MGP_FVBNJ_G0031360
protein coding gene Chr7:2180346-2248486 (-)
LP/J MGP_LPJ_G0031493
protein coding gene Chr7:2359311-2430744 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031399
protein coding gene Chr7:2541343-2605839 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032062
protein coding gene Chr7:2251281-2309275 (-)
PWK/PhJ MGP_PWKPhJ_G0030384
protein coding gene Chr7:2365108-2417368 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030209
protein coding gene Chr7:2259806-2305820 (-)
WSB/EiJ MGP_WSBEiJ_G0030751
protein coding gene Chr7:2269655-2337082 (-)



Homology
more
  • Human Ortholog
    NLRP2, NLR family pyrin domain containing 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NLRP2, NLR family pyrin domain containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLR19.9, NALP2, NBS1, PAN1, PYPAF2
  • Links
    NCBI Gene ID: 55655
    neXtProt AC: NX_Q9NX02
    UniProt: Q9NX02

  • Chr Location
    19q13.42; chr19:54965284-55001142 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232827 NCBI Gene Model | MGI Sequence Detail 52489 C57BL/6J ±  kb
transcript NM_177690 RefSeq | MGI Sequence Detail 3404 C57BL/6  
polypeptide NP_808358 RefSeq | MGI Sequence Detail 1046 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR004020 DAPIN domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR007111 NACHT nucleoside triphosphatase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 12
    cDNA 9
    Primer pair 2
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:92340 Anderson JP, et al., Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18;338(1):25-34
  • Latest
    J:244909 Peng H, et al., NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse. Reproduction. 2017 Sep;154(3):145-151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory