Cd226
Gene Detail

Symbol Name ID

Cd226 CD226 antigen MGI:3039602

Synonyms

DNAM1, DNAM-1, Pta1, TLiSA1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

59.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr18:89197431-89270201 bp, + strand From VEGA annotation of GRCm38   72771 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4787  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cd226

Human homologs

Human Homolog		CD226, CD226 molecule
NCBI Gene ID		10666
neXtProt AC		NX_Q15762
Human Synonyms		DNAM1, DNAM-1, PTA1, TLiSA1
Human Chr (Location)		18q22.3; chr18:67530192-67624232 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and increased incidence of tumor formation and mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell adhesion, cytokine production, ...
Component	cell surface, integral to membrane, ...
Function	cell adhesion molecule binding, integrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 15

Assay Type	Results
RT-PCR	2

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000014908 (Evidence)
Ensembl Gene Model	ENSMUSG00000034028 (Evidence)
Entrez Gene	225825 (Evidence)
UniGene	139293
DFCI	TC1589595, TC1594639, TC1596439, TC1679137
DoTS	DT.101341983, DT.101359238, DT.101707078, DT.97362227, DT.99852953
NIA Mouse Gene Index	U040838
Consensus CDS Project	CCDS29391.1, CCDS29392.1
International Mouse Knockout Project Status	Cd226

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014908	VEGA Gene Model | MGI Sequence Detail	72771	C57BL/6J
transcript	OTTMUST00000035415	VEGA | MGI Sequence Detail	2357	Not Applicable
polypeptide	OTTMUSP00000015835	VEGA | MGI Sequence Detail	333	Not Applicable

All sequences(46) RefSeq(5) UniProt(6)

Polymorphisms

SNPs(288 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001302	CD226 molecule

References

(Earliest) J:79321 Sherrington PD, et al., TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression. J Biol Chem. 1997 Aug 29;272(35):21735-44
(Latest) J:175415 Levin SD, et al., Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur J Immunol. 2011 Apr;41(4):902-15
All references(36)