About   Help   FAQ
Pglyrp4 Gene Detail
Summary
  • Symbol
    Pglyrp4
  • Name
    peptidoglycan recognition protein 4
  • Synonyms
    LOC242097, LOC384997, PglyrpIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686324
    NCBI Gene: 384997
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr3:90726906-90741517 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.96 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686324
protein coding gene Chr3:90726906-90741517 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027481
protein coding gene Chr3:91069977-91083797 (+)
A/J MGP_AJ_G0027445
protein coding gene Chr3:88025753-88041504 (+)
AKR/J MGP_AKRJ_G0027410
protein coding gene Chr3:90195165-90209837 (+)
BALB/cJ MGP_BALBcJ_G0027454
protein coding gene Chr3:87981922-87996495 (+)
C3H/HeJ MGP_C3HHeJ_G0027196
protein coding gene Chr3:90353356-90368790 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027900
protein coding gene Chr3:94468375-94485071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025253
protein coding gene Chr3:83520971-83535098 (+)
CAST/EiJ MGP_CASTEiJ_G0026642
protein coding gene Chr3:90756038-90775745 (+)
CBA/J MGP_CBAJ_G0027171
protein coding gene Chr3:97668686-97682992 (+)
DBA/2J MGP_DBA2J_G0027308
protein coding gene Chr3:87391887-87406662 (+)
FVB/NJ MGP_FVBNJ_G0027276
protein coding gene Chr3:85719613-85735106 (+)
LP/J MGP_LPJ_G0027417
protein coding gene Chr3:92125346-92142278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027297
protein coding gene Chr3:103927708-103949861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027959
protein coding gene Chr3:89943354-89968358 (+)
PWK/PhJ MGP_PWKPhJ_G0026376
protein coding gene Chr3:87291057-87306011 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026196
protein coding gene Chr3:89127830-89141636 (+)
WSB/EiJ MGP_WSBEiJ_G0026724
protein coding gene Chr3:90349808-90365630 (+)



Homology
more
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PGLYRPIbeta, PGRPIB, PGRP-Ibeta, SBBI67
  • Links
    NCBI Gene ID: 57115
    neXtProt AC: NX_Q96LB8
    UniProt: Q96LB8

  • Chr Location
    1q21.3; chr1:153327410-153348844 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 384997 NCBI Gene Model | MGI Sequence Detail 14612 C57BL/6J ±  kb
transcript NM_001165968 RefSeq | MGI Sequence Detail 2229 Not Specified  
polypeptide Q0VB07 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012613 peptidoglycan recognition protein 4
  • InterPro Domains
    IPR002502 N-acetylmuramoyl-L-alanine amidase domain
    IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
    IPR015510 Peptidoglycan recognition protein
    IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685259
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:252399 Dziarski R, et al., Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One. 2016;11(1):e0146162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/04/2019
MGI 6.14
The Jackson Laboratory