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Pglyrp4 Gene Detail
Summary
  • Symbol
    Pglyrp4
  • Name
    peptidoglycan recognition protein 4
  • Synonyms
    LOC242097, LOC384997, PglyrpIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686324
    NCBI Gene: 384997
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr3:90726906-90741517 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.96 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686324
protein coding gene Chr3:90726906-90741517 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027481
protein coding gene Chr3:91069977-91083797 (+)
A/J MGP_AJ_G0027445
protein coding gene Chr3:88025753-88041504 (+)
AKR/J MGP_AKRJ_G0027410
protein coding gene Chr3:90195165-90209837 (+)
BALB/cJ MGP_BALBcJ_G0027454
protein coding gene Chr3:87981922-87996495 (+)
C3H/HeJ MGP_C3HHeJ_G0027196
protein coding gene Chr3:90353356-90368790 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027900
protein coding gene Chr3:94468375-94485071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025253
protein coding gene Chr3:83520971-83535098 (+)
CAST/EiJ MGP_CASTEiJ_G0026642
protein coding gene Chr3:90756038-90775745 (+)
CBA/J MGP_CBAJ_G0027171
protein coding gene Chr3:97668686-97682992 (+)
DBA/2J MGP_DBA2J_G0027308
protein coding gene Chr3:87391887-87406662 (+)
FVB/NJ MGP_FVBNJ_G0027276
protein coding gene Chr3:85719613-85735106 (+)
LP/J MGP_LPJ_G0027417
protein coding gene Chr3:92125346-92142278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027297
protein coding gene Chr3:103927708-103949861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027959
protein coding gene Chr3:89943354-89968358 (+)
PWK/PhJ MGP_PWKPhJ_G0026376
protein coding gene Chr3:87291057-87306011 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026196
protein coding gene Chr3:89127830-89141636 (+)
WSB/EiJ MGP_WSBEiJ_G0026724
protein coding gene Chr3:90349808-90365630 (+)



Homology
more
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PGLYRPIbeta, PGRPIB, PGRP-Ibeta, SBBI67
  • Links
    NCBI Gene ID: 57115
    neXtProt AC: NX_Q96LB8
    UniProt: Q96LB8

  • Chr Location
    1q21.3; chr1:153327410-153348844 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 384997 NCBI Gene Model | MGI Sequence Detail 14612 C57BL/6J ±  kb
    transcript NM_001165968 RefSeq | MGI Sequence Detail 2229 Not Specified  
    polypeptide Q0VB07 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012613 peptidoglycan recognition protein 4
    • InterPro Domains
      IPR002502 N-acetylmuramoyl-L-alanine amidase domain
      IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
      IPR015510 Peptidoglycan recognition protein
      IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685259
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:252399 Dziarski R, et al., Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One. 2016;11(1):e0146162

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/24/2020
    MGI 6.15
    The Jackson Laboratory