About   Help   FAQ
Kalrn
Gene Detail
 Symbol
Name
ID
Kalrn
kalirin, RhoGEF kinase
MGI:2685385
Synonyms 2210407G14Rik, E530005C20Rik, Hapip, LOC224126
Feature Type protein coding gene
Genetic Map
Chromosome 16
24.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:33974258-34573532 bp, - strand
From VEGA annotation of GRCm38

  599275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Kalrn

Human
homologs
Human Homolog KALRN, kalirin, RhoGEF kinase
NCBI Gene ID 8997
neXtProt AC  NX_O60229
Human Synonyms  ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
Human Chr (Location)  3q21.2; chr3:124033498-124726325 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KALRN
Alleles
and
phenotypes
All alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axonogenesis, intracellular signal transduction, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000017795 (Evidence)
Ensembl Gene ModelENSMUSG00000061751 (Evidence)
Entrez Gene545156 (Evidence)
DFCITC1584963, TC1588542, TC1594513, TC1598665, TC1617629, TC1619230, TC1619392, TC1624328, TC1625278, TC1676834
DoTSDT.101161026, DT.101234638, DT.101369691, DT.101709026, DT.101711367, DT.40144984, DT.40177812, DT.40184451, DT.60103317, DT.91347005, DT.91397985, DT.97333490, DT.97389221, DT.99764863
EC2.7.11.1
PDB1WFW
Consensus CDS ProjectCCDS49836.1
International Mouse Knockout Project StatusKalrn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017795 VEGA Gene Model | MGI Sequence Detail 599275 C57BL/6J ±  kb
transcript OTTMUST00000043072 VEGA | MGI Sequence Detail 8940 Not Applicable 
polypeptide OTTMUSP00000019365 VEGA | MGI Sequence Detail 2964 Not Applicable 

For the selected sequences
All sequences(184) RefSeq(53) UniProt(10)
Polymorphisms SNPs within 2kb(4241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000009238 kalirin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207889 Huang S, et al., The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts. Bone. 2014 Mar;60:235-45
All references(44)
Other
accession IDs
MGI:1919628, MGI:2146601, MGI:2443174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory