Kalrn
Gene Detail

Symbol Name ID

Kalrn kalirin, RhoGEF kinase MGI:2685385

Synonyms

2210407G14Rik, E530005C20Rik, Hapip, LOC224126

Feature Type

protein coding gene

Genetic Map

Chromosome 16

24.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:33974258-34573532 bp, - strand From VEGA annotation of GRCm38   599275 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:57160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kalrn

Human homologs

Human Homolog		KALRN, kalirin, RhoGEF kinase
NCBI Gene ID		8997
neXtProt AC		NX_O60229
Human Synonyms		ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
Human Chr (Location)		3q21.2; chr3:123813558-124440036 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KALRN

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(18)
 

Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	axonogenesis, intracellular signal transduction, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, enzyme binding, ...

External Resources: FuncBase

Expression

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(21)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000017795 (Evidence)
Ensembl Gene Model	ENSMUSG00000061751 (Evidence)
Entrez Gene	545156 (Evidence)
DFCI	TC1584963, TC1588542, TC1594513, TC1598665, TC1617629, TC1619230, TC1619392, TC1624328, TC1625278, TC1676834
DoTS	DT.101161026, DT.101234638, DT.101369691, DT.101709026, DT.101711367, DT.40144984, DT.40177812, DT.40184451, DT.60103317, DT.91347005, DT.91397985, DT.97333490, DT.97389221, DT.99764863
EC	2.7.11.1
PDB	1WFW
Consensus CDS Project	CCDS49836.1
International Mouse Knockout Project Status	Kalrn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017795	VEGA Gene Model | MGI Sequence Detail	599275	C57BL/6J
transcript	OTTMUST00000043072	VEGA | MGI Sequence Detail	8940	Not Applicable
polypeptide	OTTMUSP00000019365	VEGA | MGI Sequence Detail	2964	Not Applicable

All sequences(136) RefSeq(5) UniProt(10)

Polymorphisms

SNPs(3317 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001251	CRAL-TRIO domain
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000009238	kalirin

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190577 Vanleeuwen JE, et al., Long-term perturbation of spine plasticity results in distinct impairments of cognitive function. J Neurochem. 2012 Dec;123(5):781-9
All references(39)

Other accession IDs

MGI:1919628, MGI:2146601, MGI:2443174