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Kalrn
Gene Detail
Symbol

Name
ID
Kalrn
kalirin, RhoGEF kinase
MGI:2685385
Synonyms
2210407G14Rik, E530005C20Rik, Hapip, LOC224126
Feature Type
protein coding gene
Genetic Map
Chromosome 16
24.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:33974258-34573532 bp, - strand
From VEGA annotation of GRCm38

  599275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Kalrn

Human
homologs
Human Homolog KALRN, kalirin, RhoGEF kinase
NCBI Gene ID 8997
neXtProt AC  NX_O60229
Human Synonyms  ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
Human Chr (Location)  3q21.2; chr3:124033498-124726325 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KALRN
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior.
 
Interactions
Kalrn interacts with 389 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axonogenesis, intracellular signal transduction, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017795 VEGA Gene Model | MGI Sequence Detail 599275 C57BL/6J ±  kb
transcript OTTMUST00000043072 VEGA | MGI Sequence Detail 8940 Not Applicable 
polypeptide OTTMUSP00000019365 VEGA | MGI Sequence Detail 2964 Not Applicable 

For the selected sequences
All sequences(193) RefSeq(53) UniProt(19)
Polymorphisms
SNPs within 2kb(4241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000009238 kalirin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213633 Mandela P, et al., Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning. Horm Behav. 2014 Jul;66(2):430-8
All references(45)
Other
accession IDs
MGI:1919628, MGI:2146601, MGI:2443174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory