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Kcnh6
Gene Detail
 Symbol
Name
ID
Kcnh6
potassium voltage-gated channel, subfamily H (eag-related), member 6
MGI:2684139
Synonyms m-erg2
Feature Type protein coding gene
Genetic Map
Chromosome 11
68.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:106008124-106034549 bp, + strand
From VEGA annotation of GRCm38

  26426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh6

Human
homologs
Human Homolog KCNH6, potassium voltage-gated channel, subfamily H (eag-related), member 6
NCBI Gene ID 81033
neXtProt AC  NX_Q9H252
Human Synonyms  ERG2, ERG-2, hERG-2, HERG2, Kv11.2
Human Chr (Location)  17q23.3; chr17:63523334-63548977 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Kcnh6 interacts with 91 markers (Mir15a, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function inward rectifier potassium channel activity, voltage-gated potassium channel activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (82)    Tissues (52)    Images (18)
Theiler Stages: 11, 13, 15, 19, 21, 25, 27, 28
Assay TypeResults
RNA in situ 60
RT-PCR 3
RNase protection 19
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000002939 (Evidence)
Ensembl Gene ModelENSMUSG00000001901 (Evidence)
Entrez Gene192775 (Evidence)
UniGene343850
DoTSDT.110544150, DT.55224884, DT.94191896
NIA Mouse Gene IndexU013461
Consensus CDS ProjectCCDS25545.1
International Mouse Knockout Project StatusKcnh6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002939 VEGA Gene Model | MGI Sequence Detail 26426 C57BL/6J ±  kb
transcript OTTMUST00000006034 VEGA | MGI Sequence Detail 3368 Not Applicable 
polypeptide OTTMUSP00000002851 VEGA | MGI Sequence Detail 950 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(24) UniProt(4)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR003967 Potassium channel, voltage-dependent, ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000795 voltage-gated potassium channel KCNH6
References (Earliest) J:86965 Polvani S, et al., Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Gene Expr Patterns. 2003 Dec;3(6):767-76
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory