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Kcnh6 Gene Detail
Summary
  • Symbol
    Kcnh6
  • Name
    potassium voltage-gated channel, subfamily H (eag-related), member 6
  • Synonyms
    m-erg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684139
    NCBI Gene: 192775
  • Gene Overview
    MyGene.info: KCNH6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106008124-106034549 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684139
protein coding gene Chr11:106007993-106035595 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019290
protein coding gene Chr11:109277390-109299763 (+)
A/J MGP_AJ_G0019258
protein coding gene Chr11:104629015-104651055 (+)
AKR/J MGP_AKRJ_G0019227
protein coding gene Chr11:107756341-107779754 (+)
BALB/cJ MGP_BALBcJ_G0019232
protein coding gene Chr11:105033530-105054969 (+)
C3H/HeJ MGP_C3HHeJ_G0019041
protein coding gene Chr11:108047685-108069981 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019682
protein coding gene Chr11:112633871-112659557 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017307
protein coding gene Chr11:101920047-101941131 (+)
CAST/EiJ MGP_CASTEiJ_G0018594
protein coding gene Chr11:109100392-109121442 (+)
CBA/J MGP_CBAJ_G0019010
protein coding gene Chr11:117321623-117342698 (+)
DBA/2J MGP_DBA2J_G0019122
protein coding gene Chr11:104104458-104125407 (+)
FVB/NJ MGP_FVBNJ_G0019113
protein coding gene Chr11:103608868-103629977 (+)
LP/J MGP_LPJ_G0019192
protein coding gene Chr11:109731338-109752641 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019143
protein coding gene Chr11:116617559-116640528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019719
protein coding gene Chr11:108235672-108258130 (+)
PWK/PhJ MGP_PWKPhJ_G0018359
protein coding gene Chr11:105197630-105218922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018150
protein coding gene Chr11:108010680-108031799 (+)
WSB/EiJ MGP_WSBEiJ_G0018645
protein coding gene Chr11:108210250-108231358 (+)



Homology
more
  • Human Ortholog
    KCNH6, potassium voltage-gated channel subfamily H member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNH6, potassium voltage-gated channel subfamily H member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERG2, ERG-2, hERG-2, HERG2, Kv11.2
  • Links
    NCBI Gene ID: 81033
    neXtProt AC: NX_Q9H252
    UniProt: Q9H252

  • Chr Location
    17q23.3; chr17:63523334-63548977 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001901 Ensembl Gene Model | MGI Sequence Detail 26426 C57BL/6J ±  kb
transcript ENSMUST00000001965 Ensembl | MGI Sequence Detail 3368 Not Applicable  
polypeptide ENSMUSP00000001965 Ensembl | MGI Sequence Detail 950 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR005821 Ion transport domain
    IPR000014 PAS domain
    IPR035965 PAS domain superfamily
    IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
    IPR003967 Potassium channel, voltage-dependent, ERG
    IPR030172 Potassium voltage-gated channel subfamily H member 6
    IPR014710 RmlC-like jelly roll fold
    IPR027359 Voltage-dependent channel domain superfamily
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:86965 Polvani S, et al., Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Gene Expr Patterns. 2003 Dec;3(6):767-76
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory