Kcnh6
Gene Detail

Symbol Name ID

Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 MGI:2684139

Synonyms

m-erg2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

68.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:106008124-106034549 bp, + strand From VEGA annotation of GRCm38   26426 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh6

Human homologs

Human Homolog		KCNH6, potassium voltage-gated channel, subfamily H (eag-related), member 6
NCBI Gene ID		81033
neXtProt AC		NX_Q9H252
Human Synonyms		ERG2, HERG2, Kv11.2
Human Chr (Location)		17q23.3; chr17:61600695-61626338 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	ion transport, potassium ion transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	inward rectifier potassium channel activity, voltage-gated potassium channel activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (82)    Tissues (51)    Images (18)
Theiler Stages: 11, 13, 15, 19, 21, 25, 28

Assay Type	Results
RNA in situ	60
RT-PCR	3
RNase protection	19

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000002939 (Evidence)
Ensembl Gene Model	ENSMUSG00000001901 (Evidence)
Entrez Gene	192775 (Evidence)
UniGene	343850
DoTS	DT.110544150, DT.55224884, DT.94191896
NIA Mouse Gene Index	U013461
Consensus CDS Project	CCDS25545.1
International Mouse Knockout Project Status	Kcnh6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002939	VEGA Gene Model | MGI Sequence Detail	26426	C57BL/6J
transcript	OTTMUST00000006034	VEGA | MGI Sequence Detail	3368	Not Applicable
polypeptide	OTTMUSP00000002851	VEGA | MGI Sequence Detail	950	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR003967	Potassium channel, voltage-dependent, ERG
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000795	voltage-gated potassium channel KCNH6

References

(Earliest) J:86965 Polvani S, et al., Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Gene Expr Patterns. 2003 Dec;3(6):767-76
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)