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U2af1l4 Gene Detail
Summary
  • Symbol
    U2af1l4
  • Name
    U2 small nuclear RNA auxiliary factor 1-like 4
  • Synonyms
    auxiliary factor 26, U2af26
  • Feature Type
    protein coding gene
  • IDs
    MGI:2678374
    NCBI Gene: 233073
Location & Maps
more
  • Sequence Map
    Chr7:30563301-30567960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4660 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    U2AF1L4, U2 small nuclear RNA auxiliary factor 1-like 4
  • Vertebrate Orthologs
    4
  • Human Ortholog
    U2AF1L4, U2 small nuclear RNA auxiliary factor 1-like 4
    Orthology source: HGNC
  • Synonyms
    U2AF1L3, U2AF1L3V1, U2AF1RS3, U2AF1-RS3, U2af26
  • Links
    NCBI Gene ID: 199746
    neXtProt AC: NX_Q8WU68

  • Chr Location
    19q13.12; chr19:35742527-35745442 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Targeted
    4
Mice homozygous for a null allele display abnormal circadian rhythms in response to changing external cues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036722 VEGA Gene Model | MGI Sequence Detail 4660 C57BL/6J ±  kb
transcript OTTMUST00000094125 VEGA | MGI Sequence Detail 3007 Not Applicable  
polypeptide OTTMUSP00000052294 VEGA | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 137
Protein
Information
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  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000016945 splicing factor U2AF 26 kDa subunit
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
    IPR009145 U2 auxiliary factor small subunit
    IPR000571 Zinc finger, CCCH-type
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
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MGI:2141802, MGI:2141967, MGI:2142260
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:83847 Shepard J, et al., Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol. 2002 Jan;22(1):221-30
  • Latest
    J:215244 Preussner M, et al., Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice. Mol Cell. 2014 May 22;54(4):651-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory