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Tg(KRT5-E2F1)2Dgj
Transgene Detail
Summary
Symbol: Tg(KRT5-E2F1)2Dgj
Name: transgene insertion 2, David G Johnson
MGI ID: MGI:2384616
Synonyms: 1.1, K5 E2F1
Transgene: Tg(KRT5-E2F1)2Dgj  Location: unknown  
Alliance: Tg(KRT5-E2F1)2Dgj page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL/J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT5-E2F1)2Dgj expresses 1 gene
 
Tg(KRT5-E2F1)2Dgj expression driven by 1 gene
 
Mutation detailsHuman E2F1 cDNA was adjoined to the bovine keratin promoter. Overexpression of the transgene in epidermal cells was confirmed by immunohistochemical analysis. Western blot analysis showed that the level of transgenic protein was 47 fold greater than that of the endogenous protein. (J:46535)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(KRT5-E2F1)2Dgj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:46535 Pierce AM, et al., Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene. 1998 Mar 12;16(10):1267-76
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory