L3mbtl1
Gene Detail

Symbol Name ID

L3mbtl1 l(3)mbt-like (Drosophila) MGI:2676663

Synonyms

L3MBTL1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

83.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:162943472-162974522 bp, + strand From VEGA annotation of GRCm38   31051 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: L3mbtl1

Human homologs

Human Homolog		L3MBTL1, l(3)mbt-like 1 (Drosophila)
NCBI Gene ID		26013
neXtProt AC		NX_Q9Y468
Human Synonyms		dJ138B7.3, H-L(3)MBT, L3MBTL, ZC2HC3
Human Chr (Location)		20q13.12; chr20:42136320-42170535 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit normal nervous system phenotype, hematopoietic system phenotype, immune system phenotype, cellular phenotype, and lifespan.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	chromatin modification, negative regulation of transcription, DNA-dependent, ...
Component	chromatin, condensed chromosome, ...
Function	chromatin binding, histone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (135)    Images (34)
Theiler Stages: 16, 18, 21, 22, 23

Assay Type	Results
RNA in situ	205

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000001061 (Evidence)
Ensembl Gene Model	ENSMUSG00000035576 (Evidence)
Entrez Gene	241764 (Evidence)
UniGene	187086
DFCI	TC1603820, TC1615673
DoTS	DT.101122229, DT.110674886, DT.110674891, DT.110674899, DT.110674900, DT.91392665
NIA Mouse Gene Index	U002776
Consensus CDS Project	CCDS38314.1
International Mouse Knockout Project Status	L3mbtl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001061	VEGA Gene Model | MGI Sequence Detail	31051	C57BL/6J
transcript	OTTMUST00000002105	VEGA | MGI Sequence Detail	2724	Not Applicable
polypeptide	OTTMUSP00000001015	VEGA | MGI Sequence Detail	826	Not Applicable

All sequences(50) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(126 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004092	Mbt repeat
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR002515	Zinc finger, C2HC-type
Protein Ontology	PR:000009640	lethal(3)malignant brain tumor-like protein 1

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)