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Defb14 Gene Detail
Summary
  • Symbol
    Defb14
  • Name
    defensin beta 14
  • Synonyms
    mBD14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675345
    NCBI Gene: 244332
Location & Maps
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  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    DEFB103A, defensin beta 103A
  • Vertebrate Orthologs
    2
  • Human Ortholog
    DEFB103A, defensin beta 103A
    Orthology source: HGNC
  • Synonyms
    BD-3, DEFB103, DEFB3, DEFB-3, hBD-3, HBD3, HBP3, HBP-3
  • Links
    NCBI Gene ID: 414325
    neXtProt AC: NX_P81534

  • Chr Location
    8p23.1; chr8:7881204-7882664 (+)  GRCh38.p2

  • Human Ortholog
    DEFB103B, defensin beta 103B
    Orthology source: HGNC
  • Synonyms
    BD-3, DEFB103, DEFB3, DEFB-3, HBD3, HBD-3, HBP3, HBP-3
  • Links
    NCBI Gene ID: 55894
    neXtProt AC: NX_P81534

  • Chr Location
    8p23; chr8:7428888-7430348 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
Mice homozygous for a targeted allele exhibit normal UV radiation-induced suppression of contact hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020600 VEGA Gene Model | MGI Sequence Detail 856 C57BL/6J ±  kb
transcript OTTMUST00000048804 VEGA | MGI Sequence Detail 204 Not Applicable  
polypeptide OTTMUSP00000022478 VEGA | MGI Sequence Detail 67 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006381 beta-defensin 103
  • InterPro Domains
    IPR001855 Beta defensin type
Molecular
Reagents
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  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:132395 Rohrl J, et al., Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 2008 Feb 29;283(9):5414-9
  • Latest
    J:180788 Navid F, et al., Induction of regulatory T cells by a murine beta-defensin. J Immunol. 2012 Jan 15;188(2):735-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory