About   Help   FAQ
Defb14
Gene Detail
 Symbol
Name
ID
Defb14
defensin beta 14
MGI:2675345
Synonyms mBD14
Feature Type protein coding gene
Genetic Map
Chromosome 8
10.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:19194357-19195212 bp, + strand
From VEGA annotation of GRCm38

  856 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10256  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: crotamine
Gene Tree: Defb14

Human
homologs
Human Homolog DEFB103A, defensin, beta 103A
NCBI Gene ID 414325
neXtProt AC  NX_P81534
Human Synonyms  BD-3, DEFB103, DEFB3, DEFB-3, hBD-3, HBD3, HBP3, HBP-3
Human Chr (Location)  8p23.1; chr8:7881204-7882583 (+)  GRCh38
Human Homolog DEFB103B, defensin, beta 103B
NCBI Gene ID 55894
neXtProt AC  NX_P81534
Human Synonyms  BD-3, DEFB103, DEFB3, HBD3, HBP3
Human Chr (Location)  8p23; chr8:7428888-7430160 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for a targeted allele exhibit normal UV radiation-induced suppression of contact hypersensitivity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell chemotaxis, defense response, ...
Component extracellular region
Function chemoattractant activity
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000020600 (Evidence)
Ensembl Gene ModelENSMUSG00000046354 (Evidence)
Entrez Gene244332 (Evidence)
UniGene358923
DoTSDT.101720984
Consensus CDS ProjectCCDS40253.1
International Mouse Knockout Project StatusDefb14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020600 VEGA Gene Model | MGI Sequence Detail 856 C57BL/6J ±  kb
transcript OTTMUST00000048804 VEGA | MGI Sequence Detail 204 Not Applicable 
polypeptide OTTMUSP00000022478 VEGA | MGI Sequence Detail 67 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(15) UniProt(2)
Polymorphisms SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001855 Beta defensin type
Protein Ontology PR:000006381 beta-defensin 103
References (Earliest) J:132395 Rohrl J, et al., Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 2008 Feb 29;283(9):5414-9
(Latest) J:180788 Navid F, et al., Induction of regulatory T cells by a murine beta-defensin. J Immunol. 2012 Jan 15;188(2):735-43
All references(20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory