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Defb14 Gene Detail
Summary
  • Symbol
    Defb14
  • Name
    defensin beta 14
  • Synonyms
    mBD14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675345
    NCBI Gene: 244332
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:19194357-19195212 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675345
protein coding gene Chr8:19163156-19195309 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033415
protein coding gene Chr8:16671138-16671993 (+)
A/J MGP_AJ_G0033396
protein coding gene Chr8:16103123-16103978 (+)
AKR/J MGP_AKRJ_G0033326
protein coding gene Chr8:16593917-16594772 (+)
BALB/cJ MGP_BALBcJ_G0033396
protein coding gene Chr8:16217031-16217886 (+)
C3H/HeJ MGP_C3HHeJ_G0033108
protein coding gene Chr8:16782227-16783082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033909
protein coding gene Chr8:17210451-17211306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030876
protein coding gene Chr8:15381517-15382547 (+)
CAST/EiJ MGP_CASTEiJ_G0032431
protein coding gene Chr8:16613729-16614584 (+)
CBA/J MGP_CBAJ_G0033082
protein coding gene Chr8:17980282-17981137 (+)
DBA/2J MGP_DBA2J_G0033236
protein coding gene Chr8:16052541-16053396 (+)
FVB/NJ MGP_FVBNJ_G0033184
protein coding gene Chr8:16056055-16056910 (+)
LP/J MGP_LPJ_G0033329
protein coding gene Chr8:16726595-16727450 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033221
protein coding gene Chr8:18111565-18112420 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033926
protein coding gene Chr8:16587882-16588737 (+)
PWK/PhJ MGP_PWKPhJ_G0032144
protein coding gene Chr8:16072560-16073415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031985
protein coding gene Chr8:16515689-16516544 (+)
WSB/EiJ MGP_WSBEiJ_G0032548
protein coding gene Chr8:16685554-16686409 (+)



Homology
more
  • Human Ortholog
    DEFB103A, defensin beta 103A
  • Vertebrate Orthologs
    2
  • Human Ortholog
    DEFB103A, defensin beta 103A
    Orthology source: HGNC
  • Synonyms
    BD-3, DEFB103, DEFB3, DEFB-3, HBD3, HBP3, HBP-3
  • Links
    NCBI Gene ID: 414325
    neXtProt AC: NX_P81534
    UniProt: P81534

  • Chr Location
    8p23.1; chr8:7881204-7882664 (+)  GRCh38.p7

  • Human Ortholog
    DEFB103B, defensin beta 103B
    Orthology source: HGNC
  • Synonyms
    BD-3, DEFB103, DEFB3, DEFB-3, HBD3, HBD-3, HBP3, HBP-3
  • Links
    NCBI Gene ID: 55894
    neXtProt AC: NX_P81534
    UniProt: P81534

  • Chr Location
    8p23.1; chr8:7428888-7430348 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit normal UV radiation-induced suppression of contact hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046354 Ensembl Gene Model | MGI Sequence Detail 856 C57BL/6J ±  kb
    transcript ENSMUST00000052601 Ensembl | MGI Sequence Detail 204 Not Applicable  
    polypeptide ENSMUSP00000062781 Ensembl | MGI Sequence Detail 67 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001855 Beta defensin type
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:132395 Rohrl J, et al., Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 2008 Feb 29;283(9):5414-9
    • Latest
      J:252739 Williams H, et al., Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound Healing in a Murine Model. J Invest Dermatol. 2017 Nov;137(11):2427-2436

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory