Defb14
Gene Detail

Symbol Name ID

Defb14 defensin beta 14 MGI:2675345

Synonyms

mBD14

Feature Type

protein coding gene

Genetic Map

Chromosome 8

10.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:19194357-19195212 bp, + strand From VEGA annotation of GRCm38   856 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10256  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: crotamine
Gene Tree: Defb14

Human homologs

Human Homolog		DEFB103A, defensin, beta 103A
NCBI Gene ID		414325
neXtProt AC		NX_P81534
Human Synonyms		BD-3, DEFB103, DEFB3, DEFB-3, hBD-3, HBD3, HBP3, HBP-3
Human Chr (Location)		8p23.1; chr8:7738726-7740105 (+)  GRCh37.p10
Human Homolog		DEFB103B, defensin, beta 103B
NCBI Gene ID		55894
neXtProt AC		NX_P81534
Human Synonyms		BD-3, DEFB103, DEFB3, HBD3, HBP3
Human Chr (Location)		8p23; chr8:7286410-7287682 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted allele exhibit normal UV radiation-induced suppression of contact hypersensitivity.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	defense response, defense response to bacterium
Component	extracellular region

External Resources: FuncBase

Expression

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(1) cDNA(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000020600 (Evidence)
Ensembl Gene Model	ENSMUSG00000046354 (Evidence)
Entrez Gene	244332 (Evidence)
UniGene	358923
DoTS	DT.101720984
Consensus CDS Project	CCDS40253.1
International Mouse Knockout Project Status	Defb14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020600	VEGA Gene Model | MGI Sequence Detail	856	C57BL/6J
transcript	OTTMUST00000048804	VEGA | MGI Sequence Detail	204	Not Applicable
polypeptide	OTTMUSP00000022478	VEGA | MGI Sequence Detail	67	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001855	Beta defensin type
Protein Ontology	PR:000006381	beta-defensin 103

References

(Earliest) J:132395 Rohrl J, et al., Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 2008 Feb 29;283(9):5414-9
(Latest) J:180788 Navid F, et al., Induction of regulatory T cells by a murine beta-defensin. J Immunol. 2012 Jan 15;188(2):735-43
All references(20)