T(4Mllt3;9Mll)1Thr Cytogenetic Marker Detail

Summary

• Symbol
  T(4Mllt3;9Mll)1Thr
• Name
  reciporical translocation 1, Ch 4 and Ch 9, Terrence H Rabbitts

• Feature Type
  reciprocal chromosomal translocation
• IDs
  MGI:2672005

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic

Mutations,
Alleles, and
Phenotypes

This translocation was engineered to recapitulate the leukemia-associated human T(9;11)(p22;q23) translocation. The translocation was generated by interchromosomal cre mediated recombination and results in a fusion transcript containing exon 8 of Mll andexon b of Mllt3.

References

• Summaries
  All 2
• Earliest
  J:68500 Collins EC, et al., Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 2000 Aug;1(2):127-32