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Trim50 Gene Detail
Summary
  • Symbol
    Trim50
  • Name
    tripartite motif-containing 50
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664992
    NCBI Gene: 215061
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:135353295-135368005 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664992
protein coding gene Chr5:135351873-135368005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030180
protein coding gene Chr5:139873369-139890236 (+)
A/J MGP_AJ_G0030148
protein coding gene Chr5:133887293-133903110 (+)
AKR/J MGP_AKRJ_G0030081
protein coding gene Chr5:138237963-138255665 (+)
BALB/cJ MGP_BALBcJ_G0030158
protein coding gene Chr5:135242019-135258039 (+)
C3H/HeJ MGP_C3HHeJ_G0029874
protein coding gene Chr5:138807124-138822573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030611
protein coding gene Chr5:145094803-145112535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027834
protein coding gene Chr5:128186732-128201329 (+)
CAST/EiJ MGP_CASTEiJ_G0029283
protein coding gene Chr5:138217037-138231265 (+)
CBA/J MGP_CBAJ_G0029844
protein coding gene Chr5:150789195-150808344 (+)
DBA/2J MGP_DBA2J_G0029995
protein coding gene Chr5:133796813-133813059 (+)
FVB/NJ MGP_FVBNJ_G0029950
protein coding gene Chr5:132924584-132939792 (+)
LP/J MGP_LPJ_G0030083
protein coding gene Chr5:140330735-140345492 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029982
protein coding gene Chr5:153787554-153802894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030651
protein coding gene Chr5:137982573-137999636 (+)
PWK/PhJ MGP_PWKPhJ_G0028998
protein coding gene Chr5:132830957-132847356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028833
protein coding gene Chr5:135548685-135562655 (+)
WSB/EiJ MGP_WSBEiJ_G0029357
protein coding gene Chr5:138735985-138753856 (+)



Homology
more
  • Human Ortholog
    TRIM50, tripartite motif containing 50
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIM50, tripartite motif containing 50
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRIM50A
  • Links
    NCBI Gene ID: 135892
    neXtProt AC: NX_Q86XT4
    UniProt: Q86XT4

  • Chr Location
    7q11.23; chr7:73312536-73328082 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired secretion of gastric acid with impaired stimulated tubulovesicular dynamics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053388 Ensembl Gene Model | MGI Sequence Detail 14711 C57BL/6J ±  kb
transcript ENSMUST00000111180 Ensembl | MGI Sequence Detail 1456 Not Applicable  
polypeptide ENSMUSP00000106811 Ensembl | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    Genomic 2
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Diseases 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:182796 Li HH, et al., Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med. 2009 Apr;1(1):50-65
  • Latest
    J:191586 Nishi M, et al., TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. J Biol Chem. 2012 Sep 28;287(40):33523-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory