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Wasf3 Gene Detail
Summary
  • Symbol
    Wasf3
  • Name
    WASP family, member 3
  • Synonyms
    Wave3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658986
    NCBI Gene: 245880
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146321795-146410425 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2658986
 protein coding gene Chr5:146317411-146410425 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030376
 protein coding gene Chr5:151964254-152056357 (+)
A/J MGP_AJ_G0030349
 protein coding gene Chr5:145542849-145627078 (+)
AKR/J MGP_AKRJ_G0030276
 protein coding gene Chr5:149975073-150073465 (+)
BALB/cJ MGP_BALBcJ_G0030358
 protein coding gene Chr5:146749654-146836048 (+)
C3H/HeJ MGP_C3HHeJ_G0030072
 protein coding gene Chr5:150934919-151021839 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030813
 protein coding gene Chr5:157531533-157619685 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028026
 protein coding gene Chr5:139958607-140046523 (+)
CAST/EiJ MGP_CASTEiJ_G0029474
 protein coding gene Chr5:150437480-150529844 (+)
CBA/J MGP_CBAJ_G0030050
 protein coding gene Chr5:164075333-164177368 (+)
DBA/2J MGP_DBA2J_G0030194
 protein coding gene Chr5:145207030-145304434 (+)
FVB/NJ MGP_FVBNJ_G0030148
 protein coding gene Chr5:144411447-144498758 (+)
LP/J MGP_LPJ_G0030281
 protein coding gene Chr5:152632741-152716734 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030184
 protein coding gene Chr5:166424124-166517224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030843
 protein coding gene Chr5:149884199-149979677 (+)
PWK/PhJ MGP_PWKPhJ_G0029188
 protein coding gene Chr5:144285255-144375400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029024
 protein coding gene Chr5:147146565-147246553 (+)
WSB/EiJ MGP_WSBEiJ_G0029551
 protein coding gene Chr5:150701738-150790915 (+)



Homology
more
  • Human Ortholog
    WASF3, WASP family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASF3, WASP family member 3
  • Synonyms
    Brush-1, SCAR3, WAVE3
  • Links
    NCBI Gene ID: 10810
    neXtProt AC: NX_Q9UPY6
    UniProt: Q9UPY6

  • Chr Location
    13q12.13; chr13:26539139-26688948 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Mice homozygous for a knock-out allele exhibit normal platelet physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    41
  • cDNA Data
    17
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029636 Ensembl Gene Model | MGI Sequence Detail 88631 C57BL/6J ±  kb
transcript ENSMUST00000016143 Ensembl | MGI Sequence Detail 5196 Not Applicable  
polypeptide ENSMUSP00000016143 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 17
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:83138 Sossey-Alaoui K, et al., Genomic organization and expression profile of the human and mouse WAVE gene family. Mamm Genome. 2003 May;14(5):314-22
  • Latest
    J:288274 Corral-Serrano JC, et al., PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9922-9931
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory