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Mex3c Gene Detail
Summary
  • Symbol
    Mex3c
  • Name
    mex3 RNA binding family member C
  • Synonyms
    A130001D14Rik, BM-013, Rkhd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652843
    NCBI Gene: 240396
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:73573044-73592575 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 49.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652843
protein coding gene Chr18:73572592-73592578 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024547
protein coding gene Chr18:74157276-74179928 (+)
A/J MGP_AJ_G0024514
protein coding gene Chr18:70934797-70954308 (+)
AKR/J MGP_AKRJ_G0024485
protein coding gene Chr18:73029905-73051599 (+)
BALB/cJ MGP_BALBcJ_G0024514
protein coding gene Chr18:71105998-71126085 (+)
C3H/HeJ MGP_C3HHeJ_G0024282
protein coding gene Chr18:73128864-73148917 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024960
protein coding gene Chr18:76120786-76140402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022391
protein coding gene Chr18:70019755-70039315 (+)
CAST/EiJ MGP_CASTEiJ_G0023755
protein coding gene Chr18:73295092-73316068 (+)
CBA/J MGP_CBAJ_G0024251
protein coding gene Chr18:78700043-78728379 (+)
DBA/2J MGP_DBA2J_G0024381
protein coding gene Chr18:70524796-70552689 (+)
FVB/NJ MGP_FVBNJ_G0024347
protein coding gene Chr18:69866694-69886549 (+)
LP/J MGP_LPJ_G0024465
protein coding gene Chr18:74034216-74055810 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024377
protein coding gene Chr18:80205084-80224951 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025008
protein coding gene Chr18:73156230-73177947 (+)
PWK/PhJ MGP_PWKPhJ_G0023499
protein coding gene Chr18:70888125-70908063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023303
protein coding gene Chr18:73272441-73292846 (+)
WSB/EiJ MGP_WSBEiJ_G0023818
protein coding gene Chr18:73103539-73123301 (+)



Homology
more
  • Human Ortholog
    MEX3C, mex-3 RNA binding family member C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MEX3C, mex-3 RNA binding family member C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM-013, MEX-3C, RKHD2, RNF194
  • Links
    NCBI Gene ID: 51320
    neXtProt AC: NX_Q5U5Q3
    UniProt: Q5U5Q3

  • Chr Location
    18q21.2; chr18:51174550-51197681 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 4 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozgyous for a gene trap allele exhibit strain dependent neonatal lethality and alveolar defects, growth retardation, and defects in long bone growth plate. Mice homozygous for a null allele display growth retardation and impaired cytokine production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037253 Ensembl Gene Model | MGI Sequence Detail 19532 C57BL/6J ±  kb
    transcript ENSMUST00000091852 Ensembl | MGI Sequence Detail 3738 Not Applicable  
    polypeptide ENSMUSP00000089463 Ensembl | MGI Sequence Detail 652 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3026963
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
    • Latest
      J:236334 Li X, et al., Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA. Biol Reprod. 2016 May;94(5):115

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    04/16/2019
    MGI 6.13
    The Jackson Laboratory