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Mex3c
Gene Detail
 Symbol
Name
ID
Mex3c
mex3 homolog C (C. elegans)
MGI:2652843
Synonyms A130001D14Rik, BM-013, Rkhd2
Feature Type protein coding gene
Genetic Map
Chromosome 18
49.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:73573044-73592575 bp, + strand
From VEGA annotation of GRCm38

  19532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Mex3c

Human
homologs
Human Homolog MEX3C, mex-3 RNA binding family member C
NCBI Gene ID 51320
neXtProt AC  NX_Q5U5Q3
Human Synonyms  MEX-3C, RKHD2, RNF194
Human Chr (Location)  18q21.2; chr18:51174550-51197681 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozgyous for a gene trap allele exhibit strain dependent neonatal lethality and alveolar defects, growth retardation, and defects in long bone growth plate.
 
Interactions
Mex3c interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chondrocyte hypertrophy, energy homeostasis, ...
Component cytoplasm, nucleus
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (28)    Images (3)
Theiler Stages: 17, 21, 23
Assay TypeResults
RNA in situ 28
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034065 (Evidence)
Ensembl Gene ModelENSMUSG00000037253 (Evidence)
Entrez Gene240396 (Evidence)
DFCITC1584695, TC1597631, TC1605294
DoTSDT.101136323, DT.487286, DT.94188878
NIA Mouse Gene IndexU018882, U128040
EC6.3.2.-
Consensus CDS ProjectCCDS50318.1
International Mouse Knockout Project StatusMex3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034065 VEGA Gene Model | MGI Sequence Detail 19532 C57BL/6J ±  kb
transcript OTTMUST00000086047 VEGA | MGI Sequence Detail 3738 Not Applicable 
polypeptide OTTMUSP00000046539 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(152)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000010358 RNA-binding protein MEX3C
References (Earliest) J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
(Latest) J:189503 Jiao Y, et al., Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth. Mol Biol Cell. 2012 Apr;23(8):1404-13
All references(35)
Other
accession IDs
MGI:3026963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory