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Mex3c
Gene Detail
Symbol

Name
ID
Mex3c
mex3 homolog C (C. elegans)
MGI:2652843
Synonyms
A130001D14Rik, BM-013, Rkhd2
Feature Type
protein coding gene
Genetic Map
Chromosome 18
49.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:73573044-73592575 bp, + strand
From VEGA annotation of GRCm38

  19532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: MEX3C
Gene Tree: Mex3c

Human
homologs
MEX3C, mex-3 RNA binding family member C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51320
neXtProt AC: NX_Q5U5Q3

Human Synonyms: BM-013, MEX-3C, RKHD2, RNF194

Human Chr (Location): 18q21.2; chr18:51174550-51197681 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozgyous for a gene trap allele exhibit strain dependent neonatal lethality and alveolar defects, growth retardation, and defects in long bone growth plate. Mice homozygous for a null allele display growth retardation and impaired cytokine production.
 
Interactions
Mex3c interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (28)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mex3c    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034065 (Evidence)
Ensembl Gene Model ENSMUSG00000037253 (Evidence)
Entrez Gene 240396 (Evidence)
DFCI TC1584695, TC1605294, TC1597631
DoTS DT.101136323, DT.94188878, DT.487286
NIA Mouse Gene Index U018882, U128040
EC 6.3.2.-
Consensus CDS Project CCDS50318.1
International Mouse Phenotyping Consortium Status Mex3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034065 VEGA Gene Model | MGI Sequence Detail 19532 C57BL/6J ±  kb
transcript OTTMUST00000086047 VEGA | MGI Sequence Detail 3738 Not Applicable 
polypeptide OTTMUSP00000046539 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(152)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000010358 RNA-binding protein MEX3C
References
(Earliest) J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
(Latest) J:208870 Kuniyoshi K, et al., Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51
All references(35)
Other
accession IDs
MGI:3026963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory