Mex3c
Gene Detail

Symbol Name ID

Mex3c mex3 homolog C (C. elegans) MGI:2652843

Synonyms

A130001D14Rik, BM-013, Rkhd2

Feature Type

protein coding gene

Genetic Map

Chromosome 18

49.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:73573044-73592575 bp, + strand From VEGA annotation of GRCm38   19532 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Mex3c

Human homologs

Human Homolog		MEX3C, mex-3 homolog C (C. elegans)
NCBI Gene ID		51320
neXtProt AC		NX_Q5U5Q3
Human Synonyms		MEX-3C, RKHD2, RNF194
Human Chr (Location)		18q21.2; chr18:48700920-48724051 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozgyous for a gene trap allele exhibit strain dependent neonatal lethality and alveolar defects, growth retardation, and defects in long bone growth plate.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	chondrocyte hypertrophy, energy homeostasis, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (28)    Images (3)
Theiler Stages: 17, 21, 23

Assay Type	Results
RNA in situ	28

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034065 (Evidence)
Ensembl Gene Model	ENSMUSG00000037253 (Evidence)
Entrez Gene	240396 (Evidence)
DFCI	TC1584695, TC1597631, TC1605294
DoTS	DT.101136323, DT.487286, DT.94188878
NIA Mouse Gene Index	U018882, U128040
EC	6.3.2.-
Consensus CDS Project	CCDS50318.1
International Mouse Knockout Project Status	Mex3c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034065	VEGA Gene Model | MGI Sequence Detail	19532	C57BL/6J
transcript	OTTMUST00000086047	VEGA | MGI Sequence Detail	3738	Not Applicable
polypeptide	OTTMUSP00000046539	VEGA | MGI Sequence Detail	652	Not Applicable

All sequences(38) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000010358	RNA-binding protein MEX3C

References

(Earliest) J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
(Latest) J:189503 Jiao Y, et al., Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth. Mol Biol Cell. 2012 Apr;23(8):1404-13
All references(34)

Other accession IDs

MGI:3026963