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Cyp2r1
Gene Detail
Symbol

Name
ID
Cyp2r1
cytochrome P450, family 2, subfamily r, polypeptide 1
MGI:2449771
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:114550166-114562972 bp, - strand
From VEGA annotation of GRCm38

  12807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP2R1
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2r1

Human
homologs
CYP2R1, cytochrome P450, family 2, subfamily R, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 120227
neXtProt AC: NX_Q6VVX0

Human Chr (Location): 11p15.2; chr11:14877436-14894034 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP2R1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cyp2r1 interacts with 186 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyp2r1    NEW 
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(2) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000027373 (Evidence)
Ensembl Gene Model ENSMUSG00000030670 (Evidence)
Entrez Gene 244209 (Evidence)
DFCI TC1591455, TC1593783
DoTS DT.94216590, DT.101275714, DT.94130969, DT.110986686
NIA Mouse Gene Index U029152
EC 1.14.13.15
Consensus CDS Project CCDS21761.1
International Mouse Phenotyping Consortium Status Cyp2r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027373 VEGA Gene Model | MGI Sequence Detail 12807 C57BL/6J ±  kb
transcript OTTMUST00000067692 VEGA | MGI Sequence Detail 1627 Not Applicable 
polypeptide OTTMUSP00000034091 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006125 vitamin D 25-hydroxylase
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:184751 Wang Y, et al., Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8501-4
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory