Nme7
Gene Detail

Symbol Name ID

Nme7 NME/NM23 family member 7 MGI:2449121

Synonyms

D530024H21Rik, Nm23-M7, non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), nucleoside-diphosphate kinase

Feature Type

protein coding gene

Genetic Map

Chromosome 1

71.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:164312879-164348181 bp, + strand From Ensembl annotation of GRCm38   35303 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nucleoside diphosphate kinase, NDK7 type
Gene Tree: Nme7

Human homologs

Human Homolog		NME7, NME/NM23 family member 7
NCBI Gene ID		29922
neXtProt AC		NX_Q9Y5B8
Human Synonyms		MN23H7, nm23-H7
Human Chr (Location)		1q24; chr1:169101769-169337186 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(2) Gene trapped(10)
 

Homozygous mice exhibit hydrocephaly, domed skulls and 50% exhibit situs inversus.

 
Human Diseases Modeled Using Mouse Nme7 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	brain development, ciliary receptor clustering involved in smoothened signaling pathway, ...
Component	centrosome
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (247)    Tissues (113)    Images (35)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	247

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026575 (Evidence)
Entrez Gene	171567 (Evidence)
DFCI	TC1579645, TC1590279, TC1628089, TC1629535, TC1668553
NIA Mouse Gene Index	U001020
EC	2.7.4.6
Consensus CDS Project	CCDS15436.1
International Mouse Knockout Project Status	Nme7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026575	Ensembl Gene Model | MGI Sequence Detail	35303	C57BL/6J
transcript	ENSMUST00000086028	Ensembl | MGI Sequence Detail	834	Not Applicable
polypeptide	ENSMUSP00000083192	Ensembl | MGI Sequence Detail	277	Not Applicable

All sequences(33) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(847 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001564	Nucleoside diphosphate kinase
InterPro	IPR011410	Nucleoside diphosphate kinase, NDK7
InterPro	IPR006602	Uncharacterised domain DM10
Protein Ontology	PR:000011287	nucleoside diphosphate kinase 7

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(37)

Other accession IDs

MGI:2441978