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Nme7
Gene Detail
Symbol

Name
ID
Nme7
NME/NM23 family member 7
MGI:2449121
Synonyms
D530024H21Rik, Nm23-M7, non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), nucleoside-diphosphate kinase
Feature Type
protein coding gene
Genetic Map
Chromosome 1
71.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:164304121-164437725 bp, + strand
From VEGA annotation of GRCm38

  133605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NME7
Protein SuperFamily: nucleoside diphosphate kinase, NDK7 type
Gene Tree: Nme7

Human
homologs
NME7, NME/NM23 family member 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29922
neXtProt AC: NX_Q9Y5B8

Human Synonyms: CFAP67, MN23H7, NDK7, NDK 7, nm23-H7

Human Chr (Location): 1q24; chr1:169131998-169367963 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(34) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit hydrocephaly, domed skulls and 50% exhibit situs inversus.
 
Interactions
Nme7 interacts with 81 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, ciliary receptor clustering involved in smoothened signaling pathway, ...
Component cell, centrosome, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (247)    Tissues (113)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 247
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nme7 ; ZFIN nme7    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050838 (Evidence)
Ensembl Gene Model ENSMUSG00000026575 (Evidence)
Entrez Gene 171567 (Evidence)
DFCI TC1579645, TC1590279, TC1628089, TC1629535, TC1668553
NIA Mouse Gene Index U001020
EC 2.7.4.6
Consensus CDS Project CCDS15436.1
International Mouse Phenotyping Consortium Status Nme7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050838 VEGA Gene Model | MGI Sequence Detail 133605 C57BL/6J ±  kb
transcript OTTMUST00000128811 VEGA | MGI Sequence Detail 2536 Not Applicable 
polypeptide OTTMUSP00000069274 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(1463 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001564 Nucleoside diphosphate kinase
InterPro IPR011410 Nucleoside diphosphate kinase, NDK7
InterPro IPR006602 Uncharacterised domain DM10
Protein Ontology PR:000011287 nucleoside diphosphate kinase 7
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(37)
Other
accession IDs
MGI:2441978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory