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Dcaf1 Gene Detail
Summary
  • Symbol
    Dcaf1
  • Name
    DDB1 and CUL4 associated factor 1
  • Synonyms
    B930007L02Rik, Vprbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445220
    NCBI Gene: 321006
  • Gene Overview
    MyGene.info: DCAF1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106821874-106880992 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445220
protein coding gene Chr9:106814169-106880992 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035244
protein coding gene Chr9:108663580-108731219 (+)
A/J MGP_AJ_G0035223
protein coding gene Chr9:104718851-104782298 (+)
AKR/J MGP_AKRJ_G0035155
protein coding gene Chr9:107324267-107384647 (+)
BALB/cJ MGP_BALBcJ_G0035217
protein coding gene Chr9:104404096-104462750 (+)
C3H/HeJ MGP_C3HHeJ_G0034927
protein coding gene Chr9:107742753-107801814 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035737
protein coding gene Chr9:111646418-111710452 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032635
protein coding gene Chr9:102199513-102258180 (+)
CAST/EiJ MGP_CASTEiJ_G0034238
protein coding gene Chr9:107665503-107728991 (+)
CBA/J MGP_CBAJ_G0034895
protein coding gene Chr9:115624426-115686581 (+)
DBA/2J MGP_DBA2J_G0035056
protein coding gene Chr9:104175342-104236842 (+)
FVB/NJ MGP_FVBNJ_G0035004
protein coding gene Chr9:102959242-103020253 (+)
LP/J MGP_LPJ_G0035132
protein coding gene Chr9:108874615-108935378 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035043
protein coding gene Chr9:117176120-117242183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035758
protein coding gene Chr9:107593700-107658336 (+)
PWK/PhJ MGP_PWKPhJ_G0033945
protein coding gene Chr9:104493222-104552623 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033780
protein coding gene Chr9:107669915-107734299 (+)
WSB/EiJ MGP_WSBEiJ_G0034359
protein coding gene Chr9:107500926-107562479 (+)



Homology
more
  • Human Ortholog
    DCAF1, DDB1 and CUL4 associated factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DCAF1, DDB1 and CUL4 associated factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIP, VPRBP
  • Links
    NCBI Gene ID: 9730
    neXtProt AC: NX_Q9Y4B6
    UniProt: Q9Y4B6

  • Chr Location
    3p21.2; chr3:51395867-51505620 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele die prior to E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040325 Ensembl Gene Model | MGI Sequence Detail 59119 C57BL/6J ±  kb
transcript ENSMUST00000161758 Ensembl | MGI Sequence Detail 5539 Not Applicable  
polypeptide ENSMUSP00000125730 Ensembl | MGI Sequence Detail 1512 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147535
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:264321 Schabla NM, et al., VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation. J Immunol. 2018 Aug 1;201(3):930-939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory