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Kcnh8
Gene Detail
Symbol

Name
ID
Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
MGI:2445160
Synonyms
C130090D05Rik, ELK1, Kv12.1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
27.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:52602709-52979194 bp, + strand
From VEGA annotation of GRCm38

  376486 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14332  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNH8
Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh8

Human
homologs
KCNH8, potassium channel, voltage gated eag related subfamily H, member 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 131096
neXtProt AC: NX_Q96L42

Human Synonyms: ELK, ELK1, elk3, Kv12.1

Human Chr (Location): 3p24.3; chr3:19147093-19535643 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Kcnh8 interacts with 250 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN kcnh8    NEW 
Molecular
reagents
All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000044933 (Evidence)
Ensembl Gene Model ENSMUSG00000035580 (Evidence)
Entrez Gene 211468 (Evidence)
DFCI TC1588145, TC1650221
DoTS DT.101345250, DT.55109344, DT.91555279
NIA Mouse Gene Index U018100, U288468
Consensus CDS Project CCDS57101.1
International Mouse Phenotyping Consortium Status Kcnh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044933 VEGA Gene Model | MGI Sequence Detail 376486 C57BL/6J ±  kb
transcript OTTMUST00000118100 VEGA | MGI Sequence Detail 4287 Not Applicable 
polypeptide OTTMUSP00000065953 VEGA | MGI Sequence Detail 1102 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(2307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR001610 PAC motif
InterPro IPR000700 PAS-associated, C-terminal
InterPro IPR000014 PAS domain
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR003950 Potassium channel, voltage-dependent, ELK
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000797 voltage-gated potassium channel KCNH8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:154739 Quina LA, et al., Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory