Kcnh8
Gene Detail

Symbol Name ID

Kcnh8 potassium voltage-gated channel, subfamily H (eag-related), member 8 MGI:2445160

Synonyms

C130090D05Rik, ELK1, Kv12.1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

27.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:52602763-52979033 bp, + strand From NCBI annotation of GRCm38   376271 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14332  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh8

Human homologs

Human Homolog		KCNH8, potassium voltage-gated channel, subfamily H (eag-related), member 8
NCBI Gene ID		131096
neXtProt AC		NX_Q96L42
Human Synonyms		ELK, ELK1, elk3, Kv12.1
Human Chr (Location)		3p24.3; chr3:19190017-19577135 (+)  GRCh37.p10

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	integral to membrane, membrane
Function	ion channel activity, phosphorelay sensor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	3

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000035580 (Evidence)
Entrez Gene	211468 (Evidence)
UniGene	399068
DFCI	TC1588145, TC1650221
DoTS	DT.101345250, DT.55109344, DT.91555279
NIA Mouse Gene Index	U018100, U288468
Consensus CDS Project	CCDS57101.1
International Mouse Knockout Project Status	Kcnh8

Sequences

Length	Strain/Species
genomic	211468	NCBI Gene Model | MGI Sequence Detail	376271	C57BL/6J
transcript	NM_001031811	RefSeq | MGI Sequence Detail	4305	Not Specified
polypeptide	P59111	UniProt | EBI | MGI Sequence Detail	1102	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR001610	PAC motif
InterPro	IPR000700	PAS-associated, C-terminal
InterPro	IPR000014	PAS domain
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR003950	Potassium channel, voltage-dependent, ELK
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000797	voltage-gated potassium channel KCNH8

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:154739 Quina LA, et al., Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
All references(24)