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Sik2 Gene Detail
Summary
  • Symbol
    Sik2
  • Name
    salt inducible kinase 2
  • Synonyms
    G630080D20Rik, Snf1lk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445031
    NCBI Gene: 235344
  • Gene Overview
    MyGene.info: SIK2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50892801-51009073 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445031
protein coding gene Chr9:50889644-51009081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034794
protein coding gene Chr9:49798654-49918662 (-)
A/J MGP_AJ_G0034775
protein coding gene Chr9:48280876-48397368 (-)
AKR/J MGP_AKRJ_G0034703
protein coding gene Chr9:49294018-49411643 (-)
BALB/cJ MGP_BALBcJ_G0034767
protein coding gene Chr9:48022489-48138439 (-)
C3H/HeJ MGP_C3HHeJ_G0034477
protein coding gene Chr9:49787937-49905417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035287
protein coding gene Chr9:51185031-51320398 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032200
protein coding gene Chr9:47745226-47864517 (-)
CAST/EiJ MGP_CASTEiJ_G0033799
protein coding gene Chr9:49731384-49845328 (-)
CBA/J MGP_CBAJ_G0034449
protein coding gene Chr9:53010403-53130984 (-)
DBA/2J MGP_DBA2J_G0034608
protein coding gene Chr9:48144876-48263492 (-)
FVB/NJ MGP_FVBNJ_G0034549
protein coding gene Chr9:47360856-47476333 (-)
LP/J MGP_LPJ_G0034689
protein coding gene Chr9:50162791-50286028 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034592
protein coding gene Chr9:54594018-54717502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035308
protein coding gene Chr9:49281052-49401694 (-)
PWK/PhJ MGP_PWKPhJ_G0033504
protein coding gene Chr9:48118993-48236703 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033339
protein coding gene Chr9:49582123-49704196 (-)
WSB/EiJ MGP_WSBEiJ_G0033912
protein coding gene Chr9:49280295-49402002 (-)



Homology
more
  • Human Ortholog
    SIK2, salt inducible kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIK2, salt inducible kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LOH11CR1I, QIK, SIK-2, SNF1LK2
  • Links
    NCBI Gene ID: 23235
    neXtProt AC: NX_Q9H0K1
    UniProt: Q9H0K1

  • Chr Location
    11q23.1; chr11:111602391-111726917 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit darkened hair color in an agouti background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037112 Ensembl Gene Model | MGI Sequence Detail 116273 C57BL/6J ±  kb
transcript ENSMUST00000041375 Ensembl | MGI Sequence Detail 3552 Not Applicable  
polypeptide ENSMUSP00000038761 Ensembl | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR034672 Salt-Inducible kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR017090 Serine/threonine-protein kinase, SIK1/2
    IPR015940 Ubiquitin-associated domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265038 Paulo E, et al., Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis. Sci Rep. 2018 Jul 20;8(1):11001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory