About   Help   FAQ
Ttc26 Gene Detail
Summary
  • Symbol
    Ttc26
  • Name
    tetratricopeptide repeat domain 26
  • Synonyms
    9430097H08Rik, hop, hpy, hydrocephalic-polydactyl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444853
    NCBI Gene: 264134
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:38381474-38427647 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 17.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444853
protein coding gene Chr6:38381469-38427647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030585
protein coding gene Chr6:36685287-36739523 (+)
A/J MGP_AJ_G0030558
protein coding gene Chr6:35091769-35138677 (+)
AKR/J MGP_AKRJ_G0030485
protein coding gene Chr6:36207403-36258207 (+)
BALB/cJ MGP_BALBcJ_G0030568
protein coding gene Chr6:35289545-35336243 (+)
C3H/HeJ MGP_C3HHeJ_G0030281
protein coding gene Chr6:36216216-36267476 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031022
protein coding gene Chr6:37602262-37655901 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028234
protein coding gene Chr6:33000220-33045165 (+)
CAST/EiJ MGP_CASTEiJ_G0029683
protein coding gene Chr6:36108216-36163660 (+)
CBA/J MGP_CBAJ_G0030259
protein coding gene Chr6:39060698-39111981 (+)
DBA/2J MGP_DBA2J_G0030403
protein coding gene Chr6:34911332-34957631 (+)
FVB/NJ MGP_FVBNJ_G0030357
protein coding gene Chr6:34699783-34747091 (+)
LP/J MGP_LPJ_G0030490
protein coding gene Chr6:36727704-36776017 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030393
protein coding gene Chr6:41421879-41483736 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031052
protein coding gene Chr6:36137989-36189136 (+)
PWK/PhJ MGP_PWKPhJ_G0029397
protein coding gene Chr6:34560853-34611253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029233
protein coding gene Chr6:35860273-35915676 (+)
WSB/EiJ MGP_WSBEiJ_G0029759
protein coding gene Chr6:36079738-36128910 (+)



Homology
more
  • Human Ortholog
    TTC26, tetratricopeptide repeat domain 26
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTC26, tetratricopeptide repeat domain 26
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dyf-13, DYF13, IFT56
  • Links
    NCBI Gene ID: 79989
    neXtProt AC: NX_A0AVF1
    UniProt: A0AVF1

  • Chr Location
    7q34; chr7:139133744-139191986 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11786
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTC26
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous nonsense mutation exhibit partial prenatal lethality, a hopping gait, preaxial polydactyly, male sterility due to lack of sperm flagella, impaired hearing, and patterning defects that are typical of impaired Hedgehog signaling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 264134 NCBI Gene Model | MGI Sequence Detail 46174 C57BL/6J ±  kb
transcript NM_153600 RefSeq | MGI Sequence Detail 4162 C57BL/6  
polypeptide Q8BS45 UniProt | EBI | MGI Sequence Detail 554 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029834 intraflagellar transport protein 56
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR013026 Tetratricopeptide repeat-containing domain
    IPR030511 Tetratricopeptide repeat protein 26
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10813, MGD-MRK-10927, MGI:96168
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:5206 Johnson DR, et al., Hop-sterile, a mutant gene affecting sperm tail development in the mouse. J Embryol Exp Morphol. 1971 Apr;25(2):223-36
  • Latest
    J:240543 Xin D, et al., IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development. 2017 Apr 15;144(8):1544-1553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory