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Xylt2
Gene Detail
 Symbol
Name
ID
Xylt2
xylosyltransferase II
MGI:2444797
Synonyms E030002B02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:94663851-94677515 bp, - strand
From VEGA annotation of GRCm38

  13665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xylt2

Human
homologs
Human Homolog XYLT2, xylosyltransferase II
NCBI Gene ID 64132
neXtProt AC  NX_Q9H1B5
Human Synonyms  PXYLT2, XT2, XT-II, xylT-II
Human Chr (Location)  17q21.33; chr17:50346032-50361185 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human XYLT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Xylt2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele lack most liver proteoglycans and develop many aspects of polycystic liver and kidney disease, including biliary tract hyperplasia, liver fibrosis, biliary cysts, renal tubule dilation, basement membrane abnormalities and hydronephrosis.
 
Phenotype Images(5)
Interactions
Xylt2 interacts with 126 markers (Mir18, Mir18b, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process glycosaminoglycan biosynthetic process, heparin biosynthetic process, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function acetylglucosaminyltransferase activity, protein xylosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (124)    Tissues (97)    Images (22)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 124
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000002014 (Evidence)
Ensembl Gene ModelENSMUSG00000020868 (Evidence)
Entrez Gene217119 (Evidence)
UniGene100638
DFCITC1575053
DoTSDT.101380454, DT.101726053
NIA Mouse Gene IndexU033289
EC2.4.2.26
Consensus CDS ProjectCCDS48888.1
International Mouse Knockout Project StatusXylt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002014 VEGA Gene Model | MGI Sequence Detail 13665 C57BL/6J ±  kb
transcript OTTMUST00000004063 VEGA | MGI Sequence Detail 3442 Not Applicable 
polypeptide OTTMUSP00000001954 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(7)
Polymorphisms SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003406 Glycosyl transferase, family 14
InterPro IPR024448 Xylosyltransferase
Protein Ontology PR:000017516 xylosyltransferase 2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory