Xylt2
Gene Detail

Symbol Name ID

Xylt2 xylosyltransferase II MGI:2444797

Synonyms

E030002B02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

58.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:94663851-94677515 bp, - strand From VEGA annotation of GRCm38   13665 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xylt2

Human homologs

Human Homolog		XYLT2, xylosyltransferase II
NCBI Gene ID		64132
neXtProt AC		NX_Q9H1B5
Human Synonyms		PXYLT2, XT2, XT-II, xylT-II
Human Chr (Location)		17q21.33; chr17:48423393-48438512 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human XYLT2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele lack most liver proteoglycans and develop many aspects of polycystic liver and kidney disease, including biliary tract hyperplasia, liver fibrosis, biliary cysts, renal tubule dilation, basement membrane abnormalities and hydronephrosis.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	glycosaminoglycan biosynthetic process
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	acetylglucosaminyltransferase activity, protein xylosyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (124)    Tissues (97)    Images (22)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	124

cDNA source data(111)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(111) cDNA(111)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000002014 (Evidence)
Ensembl Gene Model	ENSMUSG00000020868 (Evidence)
Entrez Gene	217119 (Evidence)
UniGene	100638
DFCI	TC1575053
DoTS	DT.101380454, DT.101726053
NIA Mouse Gene Index	U033289
EC	2.4.2.26
Consensus CDS Project	CCDS48888.1
International Mouse Knockout Project Status	Xylt2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002014	VEGA Gene Model | MGI Sequence Detail	13665	C57BL/6J
transcript	OTTMUST00000004063	VEGA | MGI Sequence Detail	3442	Not Applicable
polypeptide	OTTMUSP00000001954	VEGA | MGI Sequence Detail	865	Not Applicable

All sequences(46) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003406	Glycosyl transferase, family 14
InterPro	IPR024448	Xylosyltransferase
Protein Ontology	PR:000017516	xylosyltransferase 2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)