About   Help   FAQ
Xylt2 Gene Detail
Summary
  • Symbol
    Xylt2
  • Name
    xylosyltransferase II
  • Synonyms
    E030002B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444797
    NCBI Gene: 217119
  • Gene Overview
    MyGene.info: XYLT2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94663851-94677515 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444797
protein coding gene Chr11:94663847-94677519 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018966
protein coding gene Chr11:96776022-96789725 (-)
A/J MGP_AJ_G0018934
protein coding gene Chr11:92893588-92907339 (-)
AKR/J MGP_AKRJ_G0018904
protein coding gene Chr11:95783321-95797079 (-)
BALB/cJ MGP_BALBcJ_G0018907
protein coding gene Chr11:93342730-93356394 (-)
C3H/HeJ MGP_C3HHeJ_G0018721
protein coding gene Chr11:95866919-95880686 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019359
protein coding gene Chr11:99812919-99826583 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016990
protein coding gene Chr11:90384734-90398714 (-)
CAST/EiJ MGP_CASTEiJ_G0018276
protein coding gene Chr11:96594575-96608243 (-)
CBA/J MGP_CBAJ_G0018692
protein coding gene Chr11:103936704-103950475 (-)
DBA/2J MGP_DBA2J_G0018800
protein coding gene Chr11:92473953-92487617 (-)
FVB/NJ MGP_FVBNJ_G0018789
protein coding gene Chr11:91891822-91905558 (-)
LP/J MGP_LPJ_G0018870
protein coding gene Chr11:97315339-97330135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018816
protein coding gene Chr11:103938316-103951980 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019399
protein coding gene Chr11:96023015-96036679 (-)
PWK/PhJ MGP_PWKPhJ_G0018046
protein coding gene Chr11:93408108-93421916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017836
protein coding gene Chr11:95691719-95705476 (-)
WSB/EiJ MGP_WSBEiJ_G0018325
protein coding gene Chr11:95895055-95908719 (-)



Homology
more
  • Human Ortholog
    XYLT2, xylosyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XYLT2, xylosyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PXYLT2, SOS, XT2, XT-II, xylT-II
  • Links
    NCBI Gene ID: 64132
    neXtProt AC: NX_Q9H1B5
    UniProt: Q9H1B5

  • Chr Location
    17q21.33; chr17:50346032-50361185 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23349
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: XYLT2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human XYLT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack most liver proteoglycans and develop many aspects of polycystic liver and kidney disease, including biliary tract hyperplasia, liver fibrosis, biliary cysts, renal tubule dilation, basement membrane abnormalities and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020868 Ensembl Gene Model | MGI Sequence Detail 13665 C57BL/6J ±  kb
    transcript ENSMUST00000116349 Ensembl | MGI Sequence Detail 3442 Not Applicable  
    polypeptide ENSMUSP00000112052 Ensembl | MGI Sequence Detail 865 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:230781 Munns CF, et al., Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects. Am J Hum Genet. 2015 Jun 4;96(6):971-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory