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Nlgn3
Gene Detail
Symbol

Name
ID
Nlgn3
neuroligin 3
MGI:2444609
Synonyms
A230085M13Rik, HNL3, NL3
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:101299168-101325963 bp, + strand
From VEGA annotation of GRCm38

  26796 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23133  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nlgn3

Human
homologs
Human Homolog NLGN3, neuroligin 3
NCBI Gene ID 54413
neXtProt AC  NX_Q9NZ94
Human Synonyms  HNL3
Human Chr (Location)  Xq13.1; chrX:71144831-71171832 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NLGN3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from APF )
 
Homozygous null mice show impaired context and cued conditioning, hyperactivity, altered social behavior, less vocalization, smaller brains, and impaired olfaction. Males carrying a knock-in allele show impaired social interaction, and enhanced spatial learning and inhibitory synaptic transmission.
 
Human Diseases Modeled Using Mouse Nlgn3 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Nlgn3 interacts with 480 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process adult behavior, axon extension, ...
Component cell junction, cell surface, ...
Function cell adhesion molecule binding, neurexin family protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (47)    Tissues (33)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 4
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000018201 (Evidence)
Ensembl Gene ModelENSMUSG00000031302 (Evidence)
Entrez Gene245537 (Evidence)
UniGene121508
DFCITC1582262, TC1715828
DoTSDT.111029065, DT.87041665, DT.91339925
Consensus CDS ProjectCCDS30313.1
International Mouse Knockout Project StatusNlgn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018201 VEGA Gene Model | MGI Sequence Detail 26796 C57BL/6J ±  kb
transcript OTTMUST00000043942 VEGA | MGI Sequence Detail 8541 Not Applicable 
polypeptide OTTMUSP00000019733 VEGA | MGI Sequence Detail 845 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000460 Neuroligin
Protein Ontology PR:000011256 neuroligin-3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:202326 Chanda S, et al., Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16622-7
All references(53)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory