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Ythdf2 Gene Detail
Summary
  • Symbol
    Ythdf2
  • Name
    YTH N6-methyladenosine RNA binding protein 2
  • Synonyms
    9430020E02Rik, HGRG8, NY-REN-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444233
    NCBI Gene: 213541
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132184916-132212256 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 64.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444233
protein coding gene Chr4:132184912-132212303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028864
protein coding gene Chr4:134318717-134347065 (-)
A/J MGP_AJ_G0028823
protein coding gene Chr4:128736634-128765077 (-)
AKR/J MGP_AKRJ_G0028776
protein coding gene Chr4:132347984-132380223 (-)
BALB/cJ MGP_BALBcJ_G0028846
protein coding gene Chr4:129346808-129374434 (-)
C3H/HeJ MGP_C3HHeJ_G0028560
protein coding gene Chr4:132598812-132627124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029288
protein coding gene Chr4:139150168-139184026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026560
protein coding gene Chr4:121842045-121850148 (-)
CAST/EiJ MGP_CASTEiJ_G0027993
protein coding gene Chr4:130670342-130700335 (-)
CBA/J MGP_CBAJ_G0028526
protein coding gene Chr4:142714575-142753206 (-)
DBA/2J MGP_DBA2J_G0028675
protein coding gene Chr4:129161182-129189152 (-)
FVB/NJ MGP_FVBNJ_G0028642
protein coding gene Chr4:128010934-128037853 (-)
LP/J MGP_LPJ_G0028776
protein coding gene Chr4:134471439-134498544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028668
protein coding gene Chr4:147325233-147352799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029326
protein coding gene Chr4:132753182-132780958 (-)
PWK/PhJ MGP_PWKPhJ_G0027714
protein coding gene Chr4:125836064-125864580 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027540
protein coding gene Chr4:128624561-128654162 (-)
WSB/EiJ MGP_WSBEiJ_G0028073
protein coding gene Chr4:132946000-132957781 (-)



Homology
more
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAHL, HGRG8, NY-REN-2
  • Links
    NCBI Gene ID: 51441
    neXtProt AC: NX_Q9Y5A9
    UniProt: Q9Y5A9

  • Chr Location
    1p35.3; chr1:28736621-28769775 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32302
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YTHDF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozgyous for a knock-out allele exhibit female, but not male, infertility and preweaning lethality that is background sensitive.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 213541 NCBI Gene Model | MGI Sequence Detail 27341 C57BL/6J ±  kb
transcript NM_145393 RefSeq | MGI Sequence Detail 4078 C57BL/6  
polypeptide Q91YT7 UniProt | EBI | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:243747 Ivanova I, et al., The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. Mol Cell. 2017 Sep 21;67(6):1059-1067.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory