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Creb5 Gene Detail
Summary
  • Symbol
    Creb5
  • Name
    cAMP responsive element binding protein 5
  • Synonyms
    9430076C15Rik, Crebpa, D430026C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443973
    NCBI Gene: 231991
  • Gene Overview
    MyGene.info: CREB5
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:53287270-53700376 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3397 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443973
protein coding gene Chr6:53287224-53700376 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030755
protein coding gene Chr6:52601678-53027315 (+)
A/J MGP_AJ_G0030724
protein coding gene Chr6:50145008-50555025 (+)
AKR/J MGP_AKRJ_G0030651
protein coding gene Chr6:51877490-52286271 (+)
BALB/cJ MGP_BALBcJ_G0030736
protein coding gene Chr6:50493341-50909384 (+)
C3H/HeJ MGP_C3HHeJ_G0030449
protein coding gene Chr6:51888748-52301120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031191
protein coding gene Chr6:53760564-54203692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028397
protein coding gene Chr6:47776493-48175764 (+)
CAST/EiJ MGP_CASTEiJ_G0029852
protein coding gene Chr6:51712729-52139099 (+)
CBA/J MGP_CBAJ_G0030423
protein coding gene Chr6:55997079-56439283 (+)
DBA/2J MGP_DBA2J_G0030573
protein coding gene Chr6:50054024-50460072 (+)
FVB/NJ MGP_FVBNJ_G0030525
protein coding gene Chr6:49655671-50055923 (+)
LP/J MGP_LPJ_G0030658
protein coding gene Chr6:52550633-52972539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030559
protein coding gene Chr6:58592749-59011511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031221
protein coding gene Chr6:51809294-52223579 (+)
PWK/PhJ MGP_PWKPhJ_G0029565
protein coding gene Chr6:49683935-50098663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029399
protein coding gene Chr6:51165936-51584748 (+)
WSB/EiJ MGP_WSBEiJ_G0029929
protein coding gene Chr6:51826303-52241130 (+)



Homology
more
  • Human Ortholog
    CREB5, cAMP responsive element binding protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CREB5, cAMP responsive element binding protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREB-5, CRE-BPA
  • Links
    NCBI Gene ID: 9586
    neXtProt AC: NX_Q02930
    UniProt: Q02930

  • Chr Location
    7p15.1; chr7:28299321-28825894 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18215
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CREB5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053007 Ensembl Gene Model | MGI Sequence Detail 413107 C57BL/6J ±  kb
transcript ENSMUST00000203487 Ensembl | MGI Sequence Detail 2648 Not Applicable  
polypeptide ENSMUSP00000144851 Ensembl | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR016378 Transcription factor cyclic AMP-dependent, CRE-BP1-type
    IPR036236 Zinc finger C2H2 superfamily
    IPR013087 Zinc finger C2H2-type
Molecular
Reagents
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  • All nucleic 41
    cDNA 41

    Microarray probesets 2
Other
Accession IDs
less
MGI:2443551
References
more
  • Summaries
    All 27
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:260112 Filipova D, et al., Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory