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Pik3r5
Gene Detail
Symbol

Name
ID
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101
MGI:2443588
Synonyms
F730038I15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
41.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:68432121-68497849 bp, + strand
From VEGA annotation of GRCm38

  65729 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8627  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIK3R5
Gene Tree: Pik3r5

Human
homologs
PIK3R5, phosphoinositide-3-kinase, regulatory subunit 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23533
neXtProt AC: NX_Q8WYR1

Human Synonyms: F730038I15Rik, FOAP-2, p101, P101-PI3K

Human Chr (Location): 17p13.1; chr17:8878916-8965712 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PIK3R5

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis.
 
Interactions
Pik3r5 interacts with 220 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of phosphatidylinositol 3-kinase activity
Component cytoplasm, membrane, ...
Function 1-phosphatidylinositol-3-kinase regulator activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (24)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pik3r5    NEW 
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005944 (Evidence)
Ensembl Gene Model ENSMUSG00000020901 (Evidence)
Entrez Gene 320207 (Evidence)
UniGene 244960
DFCI TC1612282, TC1627375, TC1646393
DoTS DT.101389551, DT.101721188, DT.94165526, DT.94207992
NIA Mouse Gene Index U012791
Consensus CDS Project CCDS24865.1
International Mouse Phenotyping Consortium Status Pik3r5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005944 VEGA Gene Model | MGI Sequence Detail 65729 C57BL/6J ±  kb
transcript OTTMUST00000013236 VEGA | MGI Sequence Detail 4370 Not Applicable 
polypeptide OTTMUSP00000006138 VEGA | MGI Sequence Detail 871 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(347 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6
Protein Ontology PR:000012728 phosphoinositide 3-kinase regulatory subunit 5
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)
Other
accession IDs
MGI:2144465

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory