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Pik3r5 Gene Detail
Summary
  • Symbol
    Pik3r5
  • Name
    phosphoinositide-3-kinase, regulatory subunit 5, p101
  • Synonyms
    F730038I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443588
    NCBI Gene: 320207
  • Gene Overview
    MyGene.info: PIK3R5
Location & Maps
more
  • Sequence Map
    Chr11:68432121-68497849 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65729 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    F730038I15Rik, FOAP-2, p101, P101-PI3K
  • Links
    NCBI Gene ID: 23533
    neXtProt AC: NX_Q8WYR1

  • Chr Location
    17p13.1; chr17:8878916-8965712 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8627
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PIK3R5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PIK3R5 associations

Human Disease Mouse Models
       Ataxia-Oculomotor Apraxia 3; AOA3   OMIM: 615217
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Pik3r5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005944 VEGA Gene Model | MGI Sequence Detail 65729 C57BL/6J ±  kb
transcript OTTMUST00000013236 VEGA | MGI Sequence Detail 4370 Not Applicable  
polypeptide OTTMUSP00000006138 VEGA | MGI Sequence Detail 871 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    347 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012728 phosphoinositide 3-kinase regulatory subunit 5
  • InterPro Domains
    IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6
Molecular
Reagents
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  • All nucleic 31
    cDNA 31

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144465
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory