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Msrb3 Gene Detail
Summary
  • Symbol
    Msrb3
  • Name
    methionine sulfoxide reductase B3
  • Synonyms
    D430026P16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443538
    NCBI Gene: 320183
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:120781096-120899101 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 68.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    795 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443538
protein coding gene Chr10:120781096-120899215 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017777
protein coding gene Chr10:123980564-124104248 (-)
A/J MGP_AJ_G0017752
protein coding gene Chr10:119069077-119187083 (-)
AKR/J MGP_AKRJ_G0017715
protein coding gene Chr10:122622136-122742315 (-)
BALB/cJ MGP_BALBcJ_G0017716
protein coding gene Chr10:119456461-119577102 (-)
C3H/HeJ MGP_C3HHeJ_G0017540
protein coding gene Chr10:122822610-122942349 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018171
protein coding gene Chr10:128190850-128326395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015851
protein coding gene Chr10:113406511-113524551 (-)
CAST/EiJ MGP_CASTEiJ_G0017100
protein coding gene Chr10:123165719-123286522 (-)
CBA/J MGP_CBAJ_G0017509
protein coding gene Chr10:133423797-133563510 (-)
DBA/2J MGP_DBA2J_G0017615
protein coding gene Chr10:118204539-118320223 (-)
FVB/NJ MGP_FVBNJ_G0017610
protein coding gene Chr10:117185715-117303778 (-)
LP/J MGP_LPJ_G0017689
protein coding gene Chr10:124520839-124649804 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017639
protein coding gene Chr10:136000958-136128308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018211
protein coding gene Chr10:122632863-122750337 (-)
PWK/PhJ MGP_PWKPhJ_G0016885
protein coding gene Chr10:118302898-118422417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016676
protein coding gene Chr10:121535347-121664174 (-)
WSB/EiJ MGP_WSBEiJ_G0017161
protein coding gene Chr10:122879830-122996925 (-)



Homology
more
  • Human Ortholog
    MSRB3, methionine sulfoxide reductase B3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MSRB3, methionine sulfoxide reductase B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB74
  • Links
    NCBI Gene ID: 253827
    neXtProt AC: NX_Q8IXL7
    UniProt: Q8IXL7

  • Chr Location
    12q14.3; chr12:65278643-65466907 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Msrb3 mouse models; 1 with human MSRB3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit deafness with cochlear inner and outer hair cell degeneration and increased apoptosis in the organ of Corti.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051236 Ensembl Gene Model | MGI Sequence Detail 118006 C57BL/6J ±  kb
transcript ENSMUST00000092143 Ensembl | MGI Sequence Detail 3843 Not Applicable  
polypeptide ENSMUSP00000089781 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:235190 Kwak GH, et al., Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways. Biochem Biophys Res Commun. 2016 May 13;473(4):1033-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory