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Msrb3
Gene Detail
Symbol

Name
ID
Msrb3
methionine sulfoxide reductase B3
MGI:2443538
Synonyms
D430026P16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
68.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:120781096-120899101 bp, - strand
From VEGA annotation of GRCm38

  118006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: MSRB3
Gene Tree: Msrb3

Human
homologs
MSRB3, methionine sulfoxide reductase B3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 253827
neXtProt AC: NX_Q8IXL7

Human Synonyms: DFNB74

Human Chr (Location): 12q14.3; chr12:65278643-65466907 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MSRB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit deafness with cochlear inner and outer hair cell degeneration and increased apoptosis in the organ of Corti.
 
Human Diseases Modeled in Mice Using Msrb3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Msrb3 interacts with 337 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process oxidation-reduction process, protein repair, ...
Component endoplasmic reticulum, mitochondrion
Function metal ion binding, methionine-R-sulfoxide reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (110)    Tissues (47)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 110
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase msrb3 ; ZFIN msrb3    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027726 (Evidence)
Ensembl Gene Model ENSMUSG00000051236 (Evidence)
Entrez Gene 320183 (Evidence)
DFCI TC1585084, TC1640136, TC1603000
DoTS DT.94228235, DT.103564855
NIA Mouse Gene Index U032282
EC 1.8.4.-
Consensus CDS Project CCDS24208.1
International Mouse Phenotyping Consortium Status Msrb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027726 VEGA Gene Model | MGI Sequence Detail 118006 C57BL/6J ±  kb
transcript OTTMUST00000068610 VEGA | MGI Sequence Detail 3843 Not Applicable 
polypeptide OTTMUSP00000034729 VEGA | MGI Sequence Detail 186 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(800 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011057 Mss4-like
InterPro IPR002579 Peptide methionine sulphoxide reductase MrsB
Protein Ontology PR:000010682 methionine-R-sulfoxide reductase B3, mitochondrial
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
All references(30)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory