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Msrb3 Gene Detail
Summary
  • Symbol
    Msrb3
  • Name
    methionine sulfoxide reductase B3
  • Synonyms
    D430026P16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443538
    NCBI Gene: 320183
Location & Maps
more
  • Sequence Map
    Chr10:120781096-120899101 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118006 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 68.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MSRB3, methionine sulfoxide reductase B3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MSRB3, methionine sulfoxide reductase B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB74
  • Links
    NCBI Gene ID: 253827
    neXtProt AC: NX_Q8IXL7

  • Chr Location
    12q14.3; chr12:65278643-65466907 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Msrb3 mouse models; 1 with human MSRB3 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 74; DFNB74   OMIM: 613718 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit deafness with cochlear inner and outer hair cell degeneration and increased apoptosis in the organ of Corti.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027726 VEGA Gene Model | MGI Sequence Detail 118006 C57BL/6J ±  kb
transcript OTTMUST00000068610 VEGA | MGI Sequence Detail 3843 Not Applicable  
polypeptide OTTMUSP00000034729 VEGA | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    795 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:227874 Lee E, et al., Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways. Arch Biochem Biophys. 2014 Apr 1;547:1-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory