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Lax1 Gene Detail
Summary
  • Symbol
    Lax1
  • Name
    lymphocyte transmembrane adaptor 1
  • Synonyms
    E430019B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443362
    NCBI Gene: 240754
Location & Maps
more
  • Sequence Map
    Chr1:133679091-133690108 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11018 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.95 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAX
  • Links
    NCBI Gene ID: 54900
    neXtProt AC: NX_Q8IWV1

  • Chr Location
    1q32.1; chr1:203765146-203776372 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Lax1
  • Incidental Mutations
Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049667 VEGA Gene Model | MGI Sequence Detail 11018 C57BL/6J ±  kb
transcript OTTMUST00000126532 VEGA | MGI Sequence Detail 2309 Not Applicable  
polypeptide OTTMUSP00000068408 VEGA | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009688 lymphocyte transmembrane adapter 1
  • InterPro Domains
    IPR031393 Lymphocyte transmembrane adapter 1
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:126552 Sancho-Shimizu V, et al., Molecular genetic analysis of two Loci (ity2 and ity3) involved in the host response to infection with salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007 Oct;177(2):1125-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory