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Lax1
Gene Detail
 Symbol
Name
ID
Lax1
lymphocyte transmembrane adaptor 1
MGI:2443362
Synonyms E430019B13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:133679029-133690108 bp, - strand
From NCBI annotation of GRCm38

  11080 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Lax1

Human
homologs
Human Homolog LAX1, lymphocyte transmembrane adaptor 1
NCBI Gene ID 54900
neXtProt AC  NX_Q8IWV1
Human Synonyms  LAX
Human Chr (Location)  1q32.1; chr1:203765156-203776372 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs.
 
Interactions
Lax1 interacts with 116 markers (Mir1b, Mir20a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process antigen receptor-mediated signaling pathway, B cell activation, ...
Component cell, cytoplasm, ...
Function protein kinase binding, SH2 domain binding
External Resources: FuncBase
Expression
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051998 (Evidence)
Entrez Gene240754 (Evidence)
UniGene36534
DFCITC1583932
DoTSDT.101211184, DT.101376634, DT.486927, DT.94254424
NIA Mouse Gene IndexU120144
Consensus CDS ProjectCCDS35711.1
International Mouse Knockout Project StatusLax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 240754 NCBI Gene Model | MGI Sequence Detail 11080 C57BL/6J ±  kb
transcript NM_001159649 RefSeq | MGI Sequence Detail 2371 C57BL/6 
polypeptide Q8BHB3 UniProt | EBI | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009688 lymphocyte transmembrane adapter 1
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:126552 Sancho-Shimizu V, et al., Molecular genetic analysis of two Loci (ity2 and ity3) involved in the host response to infection with salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007 Oct;177(2):1125-39
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory