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Lax1
Gene Detail
Symbol

Name
ID
Lax1
lymphocyte transmembrane adaptor 1
MGI:2443362
Synonyms
E430019B13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:133679091-133690108 bp, - strand
From VEGA annotation of GRCm38

  11018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LAX1
Gene Tree: Lax1

Human
homologs
LAX1, lymphocyte transmembrane adaptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54900
neXtProt AC: NX_Q8IWV1

Human Synonyms: LAX

Human Chr (Location): 1q32.1; chr1:203765146-203776372 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs.
 
Interactions
Lax1 interacts with 116 markers (Mir1b, Mir20a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adaptive immune response, antigen receptor-mediated signaling pathway, ...
Component cell, cytoplasm, ...
Function protein kinase binding, SH2 domain binding
External Resources: FuncBase
Expression
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049667 (Evidence)
Ensembl Gene Model ENSMUSG00000051998 (Evidence)
Entrez Gene 240754 (Evidence)
UniGene 36534
DFCI TC1583932
DoTS DT.101211184, DT.101376634, DT.486927, DT.94254424
NIA Mouse Gene Index U120144
Consensus CDS Project CCDS35711.1
International Mouse Phenotyping Consortium Status Lax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049667 VEGA Gene Model | MGI Sequence Detail 11018 C57BL/6J ±  kb
transcript OTTMUST00000126532 VEGA | MGI Sequence Detail 2309 Not Applicable 
polypeptide OTTMUSP00000068408 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009688 lymphocyte transmembrane adapter 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:126552 Sancho-Shimizu V, et al., Molecular genetic analysis of two Loci (ity2 and ity3) involved in the host response to infection with salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007 Oct;177(2):1125-39
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory