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Lax1 Gene Detail
Summary
  • Symbol
    Lax1
  • Name
    lymphocyte transmembrane adaptor 1
  • Synonyms
    E430019B13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443362
    NCBI Gene: 240754
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:133679091-133690108 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.95 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443362
protein coding gene Chr1:133679029-133693029 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016492
protein coding gene Chr1:137285509-137298238 (-)
A/J MGP_AJ_G0016475
protein coding gene Chr1:132138585-132149593 (-)
AKR/J MGP_AKRJ_G0016440
protein coding gene Chr1:136072871-136083856 (-)
BALB/cJ MGP_BALBcJ_G0016435
protein coding gene Chr1:132472760-132483706 (-)
C3H/HeJ MGP_C3HHeJ_G0016261
protein coding gene Chr1:136170444-136181449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016896
protein coding gene Chr1:142312664-142323681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014607
protein coding gene Chr1:125287942-125298925 (-)
CAST/EiJ MGP_CASTEiJ_G0015841
protein coding gene Chr1:135209333-135220298 (-)
CBA/J MGP_CBAJ_G0016234
protein coding gene Chr1:147198184-147209062 (-)
DBA/2J MGP_DBA2J_G0016340
protein coding gene Chr1:131154218-131165926 (-)
FVB/NJ MGP_FVBNJ_G0016339
protein coding gene Chr1:129773750-129785178 (-)
LP/J MGP_LPJ_G0016411
protein coding gene Chr1:138563402-138574403 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016364
protein coding gene Chr1:152954627-152967222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016932
protein coding gene Chr1:135792385-135805248 (-)
PWK/PhJ MGP_PWKPhJ_G0015627
protein coding gene Chr1:130157406-130168761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015414
protein coding gene Chr1:134765298-134776101 (-)
WSB/EiJ MGP_WSBEiJ_G0015904
protein coding gene Chr1:135817748-135828772 (-)



Homology
more
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LAX1, lymphocyte transmembrane adaptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAX
  • Links
    NCBI Gene ID: 54900
    neXtProt AC: NX_Q8IWV1
    UniProt: Q8IWV1

  • Chr Location
    1q32.1; chr1:203765132-203778175 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051998 Ensembl Gene Model | MGI Sequence Detail 11018 C57BL/6J ±  kb
transcript ENSMUST00000169295 Ensembl | MGI Sequence Detail 2309 Not Applicable  
polypeptide ENSMUSP00000131126 Ensembl | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:126552 Sancho-Shimizu V, et al., Molecular genetic analysis of two Loci (ity2 and ity3) involved in the host response to infection with salmonella typhimurium using congenic mice and expression profiling. Genetics. 2007 Oct;177(2):1125-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory