Rimbp2 MGI Mouse Gene Detail - MGI:2443235

Symbol

Rimbp2
Name

RIMS binding protein 2
Synonyms

A930033C01Rik, mKIAA0318

Feature Type

protein coding gene
IDs

MGI:2443235
NCBI Gene: 231760
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:128834855-129030550 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 67.91 cM
Mapping Data

1 experiment

SNPs within 2kb

2044 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443235	protein coding gene	Chr5:128834852-129030636 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030121	protein coding gene	Chr5:132785640-133002825 (-)
A/J	MGP_AJ_G0030088	protein coding gene	Chr5:127213196-127415983 (-)
AKR/J	MGP_AKRJ_G0030022	protein coding gene	Chr5:131339815-131554393 (-)
BALB/cJ	MGP_BALBcJ_G0030098	protein coding gene	Chr5:128559826-128759609 (-)
C3H/HeJ	MGP_C3HHeJ_G0029815	protein coding gene	Chr5:131910752-132124864 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030551	protein coding gene	Chr5:137876764-138111395 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027776	protein coding gene	Chr5:121629449-121821984 (-)
CAST/EiJ	MGP_CASTEiJ_G0029224	protein coding gene	Chr5:131169703-131388577 (-)
CBA/J	MGP_CBAJ_G0029785	protein coding gene	Chr5:143257524-143482410 (-)
DBA/2J	MGP_DBA2J_G0029935	protein coding gene	Chr5:127197758-127401752 (-)
FVB/NJ	MGP_FVBNJ_G0029891	protein coding gene	Chr5:126260394-126464905 (-)
LP/J	MGP_LPJ_G0030024	protein coding gene	Chr5:133303341-133517671 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029922	protein coding gene	Chr5:146639388-146865403 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030592	protein coding gene	Chr5:131004561-131225222 (-)
PWK/PhJ	MGP_PWKPhJ_G0028938	protein coding gene	Chr5:126095097-126295782 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028775	protein coding gene	Chr5:128590540-128799634 (-)
WSB/EiJ	MGP_WSBEiJ_G0029298	protein coding gene	Chr5:131666290-131889787 (-)

Human Ortholog

RIMBP2, RIMS binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIMBP2, RIMS binding protein 2
Synonyms

PPP1R133, RBP2, RIM-BP2
Links

HGNC:30339

NCBI Gene ID: 23504

neXtProt AC: NX_O15034

UniProt: O15034
Chr Location

12q24.33; chr12:130396133-130768228 (-) GRCh38

MGI Vertebrate Homology

Rimbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RIMBP2
Gene Tree

Rimbp2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Rimbp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout results in a mild neurological phenotype with changes in the synaptic transmission and plasticity of hippocampal neurons.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rimbp2

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All Sequences

87
RefSeq

32
UniProt

7
CCDS

CCDS39288.1, CCDS80415.1

Ensembl

ENSMUSG00000029420 (Evidence)
NCBI Gene

231760

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029420	Ensembl Gene Model \| MGI Sequence Detail	195696	C57BL/6J	± kb
transcript	ENSMUST00000238334	Ensembl \| MGI Sequence Detail	4101	Not Applicable
polypeptide	ENSMUSP00000158659	Ensembl \| MGI Sequence Detail	1291	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014004 RIMS-binding protein 2

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR040325 RIMS-binding protein 1/2/3

IPR035753 RIMS-binding protein, second SH3 domain

IPR035755 RIMS-binding protein, third SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 22

cDNA 22

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 22
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:324135 Banerjee A, et al., Molecular and functional architecture of striatal dopamine release sites. Neuron. 2022 Jan 19;110(2):248-265.e9

TSS for Rimbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53476	Chr5:129030367-129030395 (-)	169 bp
Tssr53475	Chr5:129030111-129030130 (-)	429 bp
Tssr53474	Chr5:128981316-128981330 (-)	49,227 bp
Tssr53473	Chr5:128897117-128897146 (-)	133,418 bp
Tssr53472	Chr5:128896956-128896992 (-)	133,576 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23