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Rimbp2 Gene Detail
Summary
  • Symbol
    Rimbp2
  • Name
    RIMS binding protein 2
  • Synonyms
    A930033C01Rik, mKIAA0318
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443235
    NCBI Gene: 231760
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:128757791-128953486 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 67.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2047 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443235
protein coding gene Chr5:128757788-128953647 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030121
protein coding gene Chr5:132785640-133002825 (-)
A/J MGP_AJ_G0030088
protein coding gene Chr5:127213196-127415983 (-)
AKR/J MGP_AKRJ_G0030022
protein coding gene Chr5:131339815-131554393 (-)
BALB/cJ MGP_BALBcJ_G0030098
protein coding gene Chr5:128559826-128759609 (-)
C3H/HeJ MGP_C3HHeJ_G0029815
protein coding gene Chr5:131910752-132124864 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030551
protein coding gene Chr5:137876764-138111395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027776
protein coding gene Chr5:121629449-121821984 (-)
CAST/EiJ MGP_CASTEiJ_G0029224
protein coding gene Chr5:131169703-131388577 (-)
CBA/J MGP_CBAJ_G0029785
protein coding gene Chr5:143257524-143482410 (-)
DBA/2J MGP_DBA2J_G0029935
protein coding gene Chr5:127197758-127401752 (-)
FVB/NJ MGP_FVBNJ_G0029891
protein coding gene Chr5:126260394-126464905 (-)
LP/J MGP_LPJ_G0030024
protein coding gene Chr5:133303341-133517671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029922
protein coding gene Chr5:146639388-146865403 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030592
protein coding gene Chr5:131004561-131225222 (-)
PWK/PhJ MGP_PWKPhJ_G0028938
protein coding gene Chr5:126095097-126295782 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028775
protein coding gene Chr5:128590540-128799634 (-)
WSB/EiJ MGP_WSBEiJ_G0029298
protein coding gene Chr5:131666290-131889787 (-)



Homology
more
  • Human Ortholog
    RIMBP2, RIMS binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIMBP2, RIMS binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R133, RBP2, RIM-BP2
  • Links
    NCBI Gene ID: 23504
    neXtProt AC: NX_O15034
    UniProt: O15034

  • Chr Location
    12q24.33; chr12:130396133-130716361 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14672
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RIMBP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rimbp2
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous knockout results in a mild neurological phenotype with changes in the synaptic transmission and plasticity of hippocampal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029420 Ensembl Gene Model | MGI Sequence Detail 195696 C57BL/6J ±  kb
transcript ENSMUST00000198941 Ensembl | MGI Sequence Detail 6446 Not Applicable  
polypeptide ENSMUSP00000142455 Ensembl | MGI Sequence Detail 1079 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:238503 Grauel MK, et al., RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory