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Rimbp2 Gene Detail
Summary
  • Symbol
    Rimbp2
  • Name
    RIMS binding protein 2
  • Synonyms
    A930033C01Rik, mKIAA0318
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443235
    NCBI Gene: 231760
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:128757791-128953486 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      195696 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 67.91 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RIMBP2, RIMS binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RIMBP2, RIMS binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R133, RBP2, RIM-BP2
  • Links
    NCBI Gene ID: 23504
    neXtProt AC: NX_O15034
    UniProt: O15034

  • Chr Location
    12q24.33; chr12:130396133-130716361 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14672
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RIMBP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in a mild neurological phenotype with changes in the synaptic transmission and plasticity of hippocampal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055220 VEGA Gene Model | MGI Sequence Detail 195696 C57BL/6J ±  kb
transcript OTTMUST00000136840 VEGA | MGI Sequence Detail 6446 Not Applicable  
polypeptide OTTMUSP00000072161 VEGA | MGI Sequence Detail 1079 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2047 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:238503 Grauel MK, et al., RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/03/2018
MGI 6.11
The Jackson Laboratory